DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and UGT1A10

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_061948.1	Gene:	UGT1A10 / 54575	HGNCID:	12531	Length:	530	Species:	Homo sapiens

Alignment Length:	557	Identity:	165/557 - (29%)
Similarity:	266/557 - (47%)	Gaps:	93/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVFIPD 73
            ||||. ...:|.::|.: |..| |.:..:...:::|..|||:|.                |.:|:
Human    16 LLLTC-GFAEAGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVV----------------VVMPE 61

  Fly    74 VFNNYKELIN----ELSGPMNLWQEN---------------------------NFINKFFVSVTR 107
            |....:..:|    ..|....|..:|                           .|::.|| |..|
Human    62 VSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFF-SHCR 125

  Fly   108 CVLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESP 172
            .:..::::.|.|   .:..||.:.::...:.... .|.:|:.|.:..:......:::......:|
Human   126 SLFNDRKLVEYL---KESSFDAVFLDPFDTCGLI-VAKYFSLPSVVFTRGIFCHHLEEGAQCPAP 186

  Fly   173 LSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKY-----FPEASKRVQLT 232
            |||.|....|.:|.|||.||:.|.:           ||:  ::.::.:|     ...||:.:|..
Human   187 LSYVPNDLLGFSDAMTFKERVWNHI-----------VHL--EDHLFCQYLFRNALEIASEILQTP 238

  Fly   233 ----DLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYF 293
                ||..:.|:.||...|.|.:|:|.:||||.:||:: .|:..|||.:.|.:|..|||||::.|
Human   239 VTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGIN-CHQGKPLPMEFEAYINASGEHGIVVF 302

  Fly   294 SLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKL 358
            ||||.|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||..:.
Human   303 SLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRA 365

  Fly   359 FITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKE 423
            ||||.|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.::.:
Human   366 FITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIND 430

  Fly   424 PRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGG 488
            ..:.:...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.|| .
Human   431 KSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL-A 494

  Fly   489 ALLLVAIIV---------GVLGKLTDFGNAKKKLKSK 516
            .:|.||.|.         ..|||.   |..||..|||
Human   495 VVLTVAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	138/496 (28%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	117/451 (26%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	155/537 (29%)
UGT1A10	NP_061948.1	egt	<258..504	CDD:223071	98/249 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150344
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690