Protein Alignment Ugt35B1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_524313.2
• Gene: Ugt35B1 / 41333
• FlyBaseID: FBgn0026314
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 165/557 - (29%)
• Similarity: 266/557 - (47%)
• Gaps: 93/557 - (16%)

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVFIPD 73
            ||||. ...:|.::|.: |..| |.:..:...:::|..|||:|.                |.:|:
Human    16 LLLTC-GFAEAGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVV----------------VVMPE 61

  Fly    74 VFNNYKELIN----ELSGPMNLWQEN---------------------------NFINKFFVSVTR 107
            |....:..:|    ..|....|..:|                           .|::.|| |..|
Human    62 VSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFF-SHCR 125

  Fly   108 CVLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESP 172
            .:..::::.|.|   .:..||.:.::...:.... .|.:|:.|.:..:......:::......:|
Human   126 SLFNDRKLVEYL---KESSFDAVFLDPFDTCGLI-VAKYFSLPSVVFTRGIFCHHLEEGAQCPAP 186

  Fly   173 LSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKY-----FPEASKRVQLT 232
            |||.|....|.:|.|||.||:.|.:           ||:  ::.::.:|     ...||:.:|..
Human   187 LSYVPNDLLGFSDAMTFKERVWNHI-----------VHL--EDHLFCQYLFRNALEIASEILQTP 238

  Fly   233 ----DLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYF 293
                ||..:.|:.||...|.|.:|:|.:||||.:||:: .|:..|||.:.|.:|..|||||::.|
Human   239 VTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGIN-CHQGKPLPMEFEAYINASGEHGIVVF 302

  Fly   294 SLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKL 358
            ||||.|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||..:.
Human   303 SLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRA 365

  Fly   359 FITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKE 423
            ||||.|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.::.:
Human   366 FITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIND 430

  Fly   424 PRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGG 488
            ..:.:...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.|| .
Human   431 KSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL-A 494

  Fly   489 ALLLVAIIV---------GVLGKLTDFGNAKKKLKSK 516
            .:|.||.|.         ..|||.   |..||..|||
Human   495 VVLTVAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	Glycosyltransferase_GTB-type	<171..482	CDD:471961	114/319 (36%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	155/537 (29%)