DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	168/551 - (30%)
Similarity:	263/551 - (47%)	Gaps:	59/551 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LALRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNF 66
            |||:|    :.|.|....|.||.:|....||..:..:...:.||.|||.||.|...   ||....
  Fly     8 LALQI----VVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTIL---KPPSLH 65

  Fly    67 RD---VFIP---DVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPG-- 123
            :|   :.:|   |:.    :..|.:.|.|.....:|    .:||:.|.|   ::::||....|
  Fly    66 KDINHILVPMEEDIL----QAFNSVVGGMTKTDNSN----AYVSMFRSV---RQLSETFSKMGDV 119

  Fly   124 ------KD-------HFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSY 175
                  ||       .|||::|....:......|.....|:: ::.......:..|:||...:||
  Fly   120 MKQPLVKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLV-VALSNPPSFLGYLLGNPWEVSY 183

  Fly   176 TP----LATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNR 236
            .|    ...||  ..:.|..|:.|.:.:....| :.|:......::|.:.:.:........||::
  Fly   184 VPGMSVSIKGG--KPLGFGHRVLNLLGSMAQRL-FMFIIELRNARIYREIYGDDPTLPSYEDLHK 245

  Fly   237 NFSLVLLNQHFSLSFP-RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVL 300
            |.||:....|.....| ||.||.:||:||:.:..:|..||:::|:|: ....:|.|..|||||:.
  Fly   246 NISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLSLGSNLK 309

  Fly   301 SKDLPADRKDLILKTFASLPQRVLWKFED-DKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGG 364
            ...|.:.....:....:.|.|:|:||::| |.:||:..|:..|||.||.|:||||.:.|||||.|
  Fly   310 EDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAG 374

  Fly   365 LLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQI 429
            .....|:.:||||:|.||.|.||..|.......|||:.....|:.:....:.|..:|..|::|..
  Fly   375 KGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATA 439

  Fly   430 ARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGAL---- 490
            .:..|..|||:|:||.:|.|:|.|||:|:.||.|::.....:.:.|.::|||..|:||..:
  Fly   440 VKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCF 504

  Fly   491 ---LLVAIIVGVLGKLTDFG--NAKKKLKSK 516
               ||..::||.|.|.:...  |.|.|||.|
  Fly   505 ITKLLFGLVVGKLRKNSRKAKVNQKHKLKKK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	145/484 (30%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	124/438 (28%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	159/533 (30%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	145/488 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445795
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940