DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt37E1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	190/544 - (34%)
Similarity:	274/544 - (50%)	Gaps:	52/544 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV----NF 66
            |.|||.|:..|...|.||.:|....||..|..:..:|.||:|||.:|.|.   |.||.:    |.
  Fly    11 IAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVT---QMKPKLATHENI 72

  Fly    67 RDVFIPDVFNN---YKELINELSGPM-NLW--------QENNFINKFFVSVTRCVLTNKEVTETL 119
            ..:..|.....   .||.:.|:|... :.|        |.:|.:...:.     .:|:..|.|..
  Fly    73 TVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYE-----FMTHPNVKEIY 132

  Fly   120 LPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWN-IDALVGNESPLSYTPLATGGL 183
            ..| |..|||:.:..:.:....|.||....|:| ||..|.... :|.:|||.:..||.|.....|
  Fly   133 ENP-KIKFDLVFLGLMANTYQLGIAAKLKCPVI-ISWVGIPLPFMDTIVGNVNDPSYVPTVNVAL 195

  Fly   184 T---DRMTFLERLSNF-------VDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNF 238
            .   ..|.|..|..||       |..||  |:|:      ..:.|.:.|....:.....::.|..
  Fly   196 NAGQKTMDFGLRFVNFFKYAIMCVFETV--LDYK------MNQFYERAFANELEFPNYHEMKRRV 252

  Fly   239 SLVLLNQHFSLSFP-RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSK 302
            ||:..|.|.:...| ||.||..||:||:.:..:..||||:|.:|:..:.| |.|:||||:||.:.
  Fly   253 SLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-GAIFFSLGTNVNTN 316

  Fly   303 DLPADRKDLILKTFASLPQRVLWKFEDDK-LPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLL 366
            ....|..|::.|..:.|||||:||:||.| .||..||:|...|.||.||||||..||||||.|..
  Fly   317 TFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKG 381

  Fly   367 STIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIAR 431
            ...|:.:||.|::.||.|.||..|....|::|||..||..|||:.||::||..:|..|.:.:...
  Fly   382 GVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIG 446

  Fly   432 QMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAII 496
            :.|..|||:|::...:.|:||||||||:||.|::.......|.|.::|||.||:|..:|||:..|
  Fly   447 KFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIVTI 511

  Fly   497 VGVLGKLTD----FGNAKKKLKSK 516
            ..:..|:.:    :|:.:|.:.:|
  Fly   512 KFLFRKILNVAIGYGSQRKAVANK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	173/486 (36%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	149/440 (34%)
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	171/482 (35%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	150/439 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445753
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.840