DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	219/525 - (41%)
Similarity:	299/525 - (56%)	Gaps:	35/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVFIPD 73
            |:|.|.........|.|......|.|.......|.||..||:||.|:.|||:||:.|..||..|:
  Fly    11 LILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIKNIIDVETPN 75

  Fly    74 ---VFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPGKDH--------F 127
               |...||..|.|           |......:...|..|...::||:||...|..        |
  Fly    76 IITVMGVYKARILE-----------NAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQNRTF 129

  Fly   128 DLIIVEALRSDAYYGFAAHFNAPIIGISTFG-TDWNIDALVGNESPLSYTPLATGGLTDRMTFLE 191
            |.:|.|...:||:||||.||.||:|.:|:.| |.|..| |||..||.||.|.:.....|||.|.|
  Fly   130 DGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSD-LVGTPSPPSYVPHSLLRFGDRMNFWE 193

  Fly   192 RLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYV 256
            |..|.......:.....:::...|.:|.||||  :.:.....:.::.||||||.|.|:|.||||.
  Fly   194 RAQNLGFQIYEFAYENLINLPRHEALYRKYFP--NNKQDFYRMRKDTSLVLLNNHVSISNPRPYS 256

  Fly   257 PNMIEVGGLHISHK-PAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLP 320
            ||||||||:|::.| |.|||:::.:||: ..||||||||||||:.|||||.:::..|::|...|.
  Fly   257 PNMIEVGGMHVNRKAPKPLPQNIRKFIE-EAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLK 320

  Fly   321 QRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFY 385
            .||:||:|::....||.||.||.|.||.|||||.||..||||||||||:|||:|||||:|:|||.
  Fly   321 YRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFG 385

  Fly   386 DQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIW 450
            |||:|:.||.|.|:|:.:.:..:|....:..||.:..:|.|.:..:.:|.:||||..:||:.|::
  Fly   386 DQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVY 450

  Fly   451 WTEYVLRHKGAYHMRVAGQDLGFFAYHSLD-------VIGVLLGGALLLVAIIVGVLGKLTDFGN 508
            |.|:|.|||||.::|.|.|||.|..||:||       |||:.:....|||..:|.::.......:
  Fly   451 WVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLVTIVNGFLYKPS 515

  Fly   509 AKKKL 513
            :|.|:
  Fly   516 SKLKI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	200/469 (43%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	180/424 (42%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	165/353 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445608
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800