DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	273/518 - (52%)
Similarity:	356/518 - (68%)	Gaps:	20/518 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLALRIGFLLLTL-PASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKK-PV 63
            :..:.|.|..|:. |...::|:|||..||||.||||.|..|||.||.:|||||.:|||..|: |.
  Fly     4 LTVIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFKNKETPN 68

  Fly    64 VNFRDVFIPDVFNNYKELINELSGPMNLWQENN----FINKFFVSVTRCVLTNKEVTETLLPPGK 124
            :.|.:......|.:  |:::.|:.|: |||:.|    .:|| |:.||    ...|..:.||..|
  Fly    69 MRFIEALKAHEFAD--EMMSLLNVPL-LWQQLNAMDYILNK-FIDVT----MEDEGVQRLLNSG- 124

  Fly   125 DHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRMTF 189
            :.|||::.|.|..:..|.||.||||.::|.|:||||..||...||.||:||.||.|...||||||
  Fly   125 ETFDLVLAEMLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPISYNPLVTSPRTDRMTF 189

  Fly   190 LERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRP 254
            ||||.|..:..|..::..|||:.....:|.||||.|.|  .|.::..:|||:||.||||||:|||
  Fly   190 LERLENHYEVIVEDIHRHFVHLPHMRNVYKKYFPNAKK--TLEEVMDSFSLILLGQHFSLSYPRP 252

  Fly   255 YVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASL 319
            |:||||||||:||||||.|||:|:::||:|| .|||||||:||||.|||||.:.:|.:|||||.|
  Fly   253 YLPNMIEVGGMHISHKPKPLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKL 316

  Fly   320 PQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFF 384
            .||||||||||.:||||:||.|.||:|||||||||.|||||:||||||:.||::.|||:||||.|
  Fly   317 KQRVLWKFEDDDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCF 381

  Fly   385 YDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAI 449
            |||.:||:||.:.|||||||...:.|::|::.|:.||.:|.:|:.:..:||||||||.|.:|.|:
  Fly   382 YDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAV 446

  Fly   450 WWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVGVLGKLTDFGNAKKK 512
            ||||||:||.||.|:|...:||.|...:|||.:.|:|...|||..:||.:..||  .|..|:|
  Fly   447 WWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKL--LGGKKQK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	253/463 (55%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	227/416 (55%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	257/477 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	1	0.950	-	0	Normalized mean entropy	S5046
OMA	1	1.010	-	-		QHG27372
OrthoDB	1	1.010	-	-		D55476at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	13	12.830