DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	271/517 - (52%)
Similarity:	364/517 - (70%)	Gaps:	6/517 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLALRIGFLLLT-LPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV 64
            ||.||:..|::. ||..::.||||.:||.|..|.|.:.:||||:||:.||::|||:.||.|:||.
  Fly     5 MLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVA 69

  Fly    65 NFRDVFIPDVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPGKDHFDL 129
            |..|:.:|::|:|.:|::..|:.....|.|..:||::.:.:...||.|..|...:|.|....|||
  Fly    70 NIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVRREILQPESLQFDL 134

  Fly   130 IIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRMTFLERLS 194
            |||:..|.||.||.||:|:||||||:::||||.||.||||.|||:|....:....|..|:..||.
  Fly   135 IIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLG 199

  Fly   195 NFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNM 259
            :|||.::||:|:.:.|....|.:|.||||:.:.:..|:::.|||:|:|:||||:::.|||||||:
  Fly   200 HFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNI 264

  Fly   260 IEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVL 324
            |||||:|:..:|..||:|||:||||:|||||||||||:||.|::|..||:.:::.||||||||:|
  Fly   265 IEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRIL 329

  Fly   325 WKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFL 389
            |||:.|:|...||||.||.||||.||||||.||||||||||.||:|.||.|.|:||||||||||.
  Fly   330 WKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFR 394

  Fly   390 NVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEY 454
            |:......|.||.|::..||..|.|:||..||.|..|...|::.::|||||||:|||||||||.|
  Fly   395 NMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHY 459

  Fly   455 VLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVGVLGKLTDFGNAKKKLKSK 516
            |||||||.||||||::|.|..||||||:|..|.....:::|:|....||     .:..||||
  Fly   460 VLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKL-----LRAILKSK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	245/458 (53%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	213/411 (52%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	248/457 (54%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	215/413 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445572
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	1	0.950	-	0	Normalized mean entropy	S5046
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55476at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	13	12.750