DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	179/515 - (34%)
Similarity:	259/515 - (50%)	Gaps:	53/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SQYINVVPYLKELANRGHQV---------------TSV---NAFPQKKPVVNFRDVFIPDVFNNY 78
            |.::|:...|.||..:||:|               ||.   .:||....:.:...:|: |..|
  Rat    34 SHWLNLKIILSELVKKGHEVVVLKPSVSFSYEVDKTSAIEFESFPSSYSIADVEVIFM-DCVN-- 95

  Fly    79 KELINELSGPMNLWQENNFINKFFVSVT-------RCVLTNKEVTETLLPPGKDHFDLIIVEALR 136
             |.|.||. ..:.|.....:.|.|...:       |....|||:...|...|   ||:|:.:...
  Rat    96 -ESIYELP-KQSFWGYFLMLQKLFERTSDYSERLCRDAAFNKELMTKLQNSG---FDVILADPFT 155

  Fly   137 --SDAYYGFAAHFNAPIIGISTFGTDWNIDALVGN-ESPLSYTPLATGGLTDRMTFLERLSNFVD 198
              .|.   .|.....|::....|......:...|. ..|.||.|:|...|:|||||:||:.:.:.
  Rat   156 PCGDL---LAEILKIPLVYSLRFFPGSTYEKYSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIY 217

  Fly   199 TTVAWLNYRFVHMSEQEKMYAKYFPEASKR-VQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEV 262
            .    |.:.|......||.:.:.:.|...| ..|::......:.|:..::.|.||.|.:||...|
  Rat   218 V----LCFDFWFQVFDEKKWNELYTEVLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFV 278

  Fly   263 GGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWK 326
            ||||.  :|| ||||::|:|:|.||||||:.|||||.|.|  |..:|.::|....|.:||:|||:
  Rat   279 GGLHC--RPAKPLPKEIEDFVQSSGEHGVVVFSLGSMVGS--LTEERANVIAAGLAQIPQKVLWR 339

  Fly   327 FEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNV 391
            ||..|.....||..:.||.||.|:|.|||.:.||||||.....|:|:||.||:|:|.|.||..|:
  Rat   340 FEGKKPETLGSNTRLYKWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNI 404

  Fly   392 RRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVL 456
            ......|..:.||..||:..:|...:..:..:|.:.:.|.::|..:.|||:.|||.|::|.|:|:
  Rat   405 VHLKTKGAAVRLDFLTMSSTDLLTALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVM 469

  Fly   457 RHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAII----VGVLGKLTDFGNAKKK 512
            |||||.|:||||.||.:..||||||||.||...:.::.|:    :....|.|..|..|||
  Rat   470 RHKGAKHLRVAGHDLSWVQYHSLDVIGFLLACVVTVMFILKKCCLFCCQKFTKAGRKKKK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	156/463 (34%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	140/435 (32%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	176/511 (34%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	112/241 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344073
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690