DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt36A1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	172/551 - (31%)
Similarity:	271/551 - (49%)	Gaps:	60/551 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLLTL------PASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKP 62
            ||.|.|::.|      |..:.|..|||::|..|.|.:..|:|.|.|||:|||.:|.::..  |.|
  Fly     5 LRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYV--KNP 67

  Fly    63 VVNFRDVFIPDVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLT---------------- 111
            ...        .:.||:||:....|..   |.:..||  .|.:|....|
  Fly    68 QAG--------AYPNYEELLISAPGED---QSSTTIN--LVPLTEHTPTRSLGVLIREYVDLHEE 119

  Fly   112 NKEVTETLLPPG------KDH----FDLIIVEALRSDAYYGFAAHFNAPIIGISTFG-TDWNIDA 165
            .::..|.|...|      :.|    :||::.|...||.....|...|.||||:||.. ..:..|.
  Fly   120 GQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDR 184

  Fly   166 LVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQ 230
            :...::| ::......|...::.:.|||.|||...:....|::.......::..||.   ...|.
  Fly   185 IDLPDTP-AFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYL---GVEVD 245

  Fly   231 LTDLNR-NFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHK-PAPLPKDLEEFIQGSGEHGVIYF 293
            :.::.| ..:.:..|||:||...||.....:|:||:||:.| ...||:::..|:..|.| |||:.
  Fly   246 VEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFI 309

  Fly   294 SLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFI-SKWFPQPDILAHPKVK 357
            |.||.|.:..:..|:...||:...|.|.:::||:|.|:.|...::.|: .||.||..:|.|||||
  Fly   310 SWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVK 374

  Fly   358 LFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLK 422
            ||.:|||||.|.||:|.|||:|..|.:.|||||.......|.||.||:..:|...||:.:..|.|
  Fly   375 LFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSK 439

  Fly   423 EPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHK--GAYHMRVAGQDLGFFAYHSLDVIGVL 485
            . .:||.:.::|:.:.::..:||::|||..|:|:.:.  .|..::..|.:|..|.|||||.:.::
  Fly   440 N-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALI 503

  Fly   486 LGGALLLVAIIVGVLGKLTDFGNAKKKLKSK 516
            |...:||: :::..|.|......|.||:..|
  Fly   504 LLPLILLI-LVLCYLCKRNPSKLAHKKVGKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	152/495 (31%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	137/441 (31%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	152/487 (31%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	151/483 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454665
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100631at6960
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	8.000