DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	173/508 - (34%)
Similarity:	289/508 - (56%)	Gaps:	23/508 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLLTLPASM-------QAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKK 61
            :|:.:..|||...:       |||.||.|||:...|.:..:.|.::.||.|||.||.:.......
  Fly     1 MRLRYCWLTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPN 65

  Fly    62 PVVNFRDVFIPDVFNNYKELINE---LSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPG 123
            .:...|.:.:..:....||::..   |...:|.|.|:....|...:.:..:|::..| :.:|...
  Fly    66 DIEGVRHIRVAQLNERIKEMLESDQVLDFMINKWTESALTAKALFNASNDILSDPGV-QRMLHDK 129

  Fly   124 KDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRMT 188
            .:.|||||:|....||.||....:||.::|:|:...:|:...|.||.:|..|.|::..|.:...:
  Fly   130 SESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIYEPISPVGFSLETS 194

  Fly   189 FLERLSNFVDTTVAWL-NYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFP 252
            ...|:.|::......| ||..:..: |..::.|:|..::::  :.:|...|||:|:|.|:|:...
  Fly   195 LFSRVYNWIHIMEEKLVNYLILRPA-QLHLFQKFFGYSAQK--MNELRSRFSLMLINSHYSMGKV 256

  Fly   253 RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFA 317
            |...||:|||||||:|..|.|..::|::|:. ..:|||||||:|:::|.|.||.:.::|:|:|||
  Fly   257 RANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVIYFSMGNDILIKFLPENIQELLLQTFA 320

  Fly   318 SLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLP 382
            :|.:.::||.|...:|.|..||::.:..||..||.||.|:||||:|||||.||::..|.|:||||
  Fly   321 TLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLP 385

  Fly   383 FFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDT 447
            .|:|||.|:|....:|....:|..::.:..|.|||:.:|....:...|:::|:.::|:|||||||
  Fly   386 MFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDT 450

  Fly   448 AIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVI-------GVLLGGALLLV 493
            |:|||||.||::....||:..:::....|:.:|.|       |::....:.||
  Fly   451 AVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	165/468 (35%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	139/415 (33%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	161/445 (36%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	160/468 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445587
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55476at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800