DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	182/520 - (35%)
Similarity:	278/520 - (53%)	Gaps:	39/520 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLALRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVN 65
            :||:.||.::    .|.|.|.||.:||...||..|..:...|.||..||.||.|...   |||||
  Fly    10 LLAIAIGAVM----GSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVL---KPVVN 67

  Fly    66 FRDVFIPDVFNNYKELINELSGPMNLWQENNFIN------------KFFVSVTRCVLTNKEVTET 118
            .:::.:..|..: ||...::|..:....:|:..|            .|.:......|.|..|.:.
  Fly    68 HKNITVIQVPLS-KEEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDL 131

  Fly   119 LLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPL---AT 180
            .|..| :.|||:|.....:|...|||...|||:|.::|...:..::.|:||...:||..:   |.
  Fly   132 YLNRG-NKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAGISNPAE 195

  Fly   181 GGLTDRMTFLERLSNFVDTTVAWLNYR-FVHMSEQ--EKMYAKYFPEASKRVQLTDLNRNFSLVL 242
            |  :..:||..|||:::.:    |.:. |.|:||:  ...|.:.:....|..:.:::.:|.|||.
  Fly   196 G--SKAVTFQRRLSSYMQS----LGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLKNTSLVF 254

  Fly   243 LNQHFSLSFP-RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPA 306
            .:.|.:...| ||.||:.||:||:.|..||.|||:::.||: |:...|.|..||||||..|.|..
  Fly   255 FSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQGKHLNP 318

  Fly   307 DRKDLILKTFASLPQRVLWKFED-DKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIE 370
            |....:....:.|.:||:||:|| :..|||.:|:..|||.||.||||||.:||||.|.|.....|
  Fly   319 DTVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITE 383

  Fly   371 SIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSE 435
            |.:||||:|.||.|.||..|.....::||||.|...|:.::..:|.|..:|..|::|:..:..|.
  Fly   384 SQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFST 448

  Fly   436 RYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDV---IGVLLGGALLLVAIIV 497
            .|||:||:..::.::|||||:||.||.|::.....:.|.|.:::|:   |.|:|...|:|:..:|
  Fly   449 LYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVSVLVLIKFLV 513

Fly 498 497
Fly 514 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	169/477 (35%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	149/431 (35%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	175/495 (35%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	170/489 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445781
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.990