DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	169/564 - (29%)
Similarity:	262/564 - (46%)	Gaps:	100/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GFLLL--TLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDV 69
            |.|||  .||.: :..::| :||..| |.::::...::||..||||  :|...|:....:...|.
  Rat    14 GLLLLLCALPWA-EGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQ--AVVLAPEVTVHMKGEDF 73

  Fly    70 F------IPDVFNNYKELINELSGPMNLWQENNFINKFFVSVT-------------RCVLTNKEV 115
            |      .|.....|:..|  |......::..:|:..||.::.             ..:|.||.:
  Rat    74 FTLQTYAFPYTKEEYQREI--LGNAKKGFEPQHFVKTFFETMASIKKFFDLYANSCAALLHNKTL 136

  Fly   116 TETLLPPGKDHFDLIIVE------ALRSDAYYGFAAHFNAPII--------GISTFGTDWNIDAL 166
            .:.|   ....||:::.:      ||       .|.:...|.:        ||....|..
  Rat   137 IQQL---NSSSFDVVLTDPVFPCGAL-------LAKYLQIPAVFFLRSVPCGIDYEATQC----- 186

  Fly   167 VGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFV-HMSEQEKMYAKYFPEASKRVQ 230
               ..|.||.|.....|:|.||||:|:.|.:..    |..::: |:|     ...|...||:.:|
  Rat   187 ---PKPSSYIPNLLTMLSDHMTFLQRVKNMLYP----LTLKYICHLS-----ITPYESLASELLQ 239

  Fly   231 LTDLNRNFSLVLLNQH---------FSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSG 286
                 |..|||.:..|         |...:|||.:|||:.:||::...| .||.::.|.::..||
  Rat   240 -----REMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIK-KPLSQEFEAYVNASG 298

  Fly   287 EHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDIL 351
            |||::.|||||.|  .::|..:...|.:....:||.|||::...:......|..:.||.||.|:|
  Rat   299 EHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLL 361

  Fly   352 AHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKET 416
            .|||.:.||||.|.....|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:|:..
  Rat   362 GHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENA 426

  Fly   417 IEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDV 481
            ::.::....:.:...::|..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||||||
  Rat   427 LKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDV 491

  Fly   482 IGVLLGGALLLVAIIVGVL---------GKLTDFGNAKKKLKSK 516
            ||.||...|.:|.|:....         ||    |..||..|||
  Rat   492 IGFLLAIVLTVVFIVYKSCAYGCRKCFGGK----GRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	143/502 (28%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	121/454 (27%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	158/540 (29%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	95/248 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860