DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_964007.2	Gene:	Ugt1a1 / 394436	MGIID:	98898	Length:	535	Species:	Mus musculus

Alignment Length:	562	Identity:	167/562 - (29%)
Similarity:	269/562 - (47%)	Gaps:	85/562 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LALRIGFLLLTL--PASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSV----NAFPQK 60
            |.|.:.:|||.:  |::..|.|:| :||..| |.:::::..:::|..:||:|..:    :...::
Mouse    10 LLLLLPYLLLCVFGPSASHAGRLL-VFPMDG-SHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKE 72

  Fly    61 KPVVNFRDVFIPDVFNNYKELINELSGPMNLWQENNF---INKFFVSVTR--------C--VLTN 112
            ......|...:|....|....:.||.  ...:.:::|   :.|.::.|.|        |  :|.|
Mouse    73 GSFYTLRKFPVPFQKENVTATLVELG--RTAFNQDSFLLRVVKIYMKVKRDSSMLLAGCSHLLHN 135

  Fly   113 KEVTETLLPPGKDHFDLIIVEALRSDAYYG----FAAHFNAPII--------GISTFGTDWNIDA 165
            .|...:|   .:.|||     ||.:|.:..    .|.:...|.:        .:.:..|...:
Mouse   136 AEFMASL---EESHFD-----ALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPV-- 190

  Fly   166 LVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEAS---- 226
                  ||||.|.:....:|||.||:|:.|.:           :.:||.......|.|..|
Mouse   191 ------PLSYVPKSLSFNSDRMNFLQRVKNVL-----------LAVSENFMCRVVYSPYGSLATE 238

  Fly   227 ---KRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEH 288
               |.|.:.||....|:.|:...|...:|||.:|||:.:||::...| .||.::.|.::..||||
Mouse   239 ILQKEVTVQDLLSPASIWLMRSDFVKDYPRPIMPNMVFIGGINCLQK-KPLSQEFEAYVNASGEH 302

  Fly   289 GVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAH 353
            |::.|||||.|  .::|..:...|.:....:||.|||::...:......|..:.||.||.|:|.|
Mouse   303 GIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGH 365

  Fly   354 PKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIE 418
            ||.:.||||.|.....|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:|:..::
Mouse   366 PKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALK 430

  Fly   419 ILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIG 483
            .::....:.:...::|..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||||||||
Mouse   431 TVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG 495

  Fly   484 VLLGGALLLVAIIVGVL---------GKLTDFGNAKKKLKSK 516
            .||...|.:|.|:....         ||    |..||..|||
Mouse   496 FLLAIVLTVVFIVFKCCAYGCRKCFGGK----GRVKKSHKSK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	140/495 (28%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	117/447 (26%)
Ugt1a1	NP_964007.2	egt	20..507	CDD:223071	153/520 (29%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	155/533 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840307
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690