DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	547	Identity:	167/547 - (30%)
Similarity:	262/547 - (47%)	Gaps:	66/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT----SVNAFPQKKPVVNF 66
            :|.|||......:..::| :||. |.|.::::...::||..:|||..    .||...:::....|
Mouse    11 VGLLLLCALPWTEGEKVL-VFPV-GGSHWLSMRDVVRELHAQGHQTVVLAPEVNMRIKEEDFFTF 73

  Fly    67 RDVFIPDVFNNYKELINELSGPMNLWQENNFINKFF-----------VSVTRC--VLTNKEVTET 118
            :...:|......:|::..|.   ..:...|::.|.|           |.:..|  :|.|:.:...
Mouse    74 KVYAVPYTRQELEEMMENLK---VFFDTGNYMKKIFKTSEALRNMSTVLLKTCTNILHNESLLHH 135

  Fly   119 LLPPGKDHFDLIIVE------ALRSDAYYGFAAHFNAPII--GISTFGTDWNIDALVGNESPLSY 175
            |   ....||::..:      ||.: .|.|..|.|....|  ||....|..        .||.||
Mouse   136 L---NSSSFDVVFTDPVFPCGALLA-KYLGIPAVFFLRYIPCGIEYEATQC--------PSPSSY 188

  Fly   176 TPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHM--SEQEKMYAKYFPEASKRVQLTDLNRNF 238
            .|.....|:|.|.||:|:.|.:...|  |.| ..|:  :..|.:.::.|   .:.|...:|....
Mouse   189 IPNLFTRLSDHMDFLQRVQNMLYHLV--LKY-ICHLLITPYESLASELF---QREVSSVELFSYA 247

  Fly   239 SLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKD 303
            |:.|....|.|.:|||.:|||:.:||::...| .||.::.|.::..|||||::.|||||.|  .:
Mouse   248 SVWLFRGDFVLDYPRPIMPNMVFIGGINCVTK-KPLSQEFEAYVNASGEHGIVVFSLGSMV--SE 309

  Fly   304 LPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLST 368
            :|..:...|.:....:||.|||::...:......|..:.||.||.|:|.|||.:.||||.|....
Mouse   310 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGI 374

  Fly   369 IESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQM 433
            .|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:|:..::.::....:.:...::
Mouse   375 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 439

  Fly   434 SERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVG 498
            |..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||||||||.||...|.:|.|:..
Mouse   440 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFK 504

  Fly   499 VL---------GKLTDFGNAKKKLKSK 516
            ..         ||    |..||..|||
Mouse   505 CCAYGCRKCFGGK----GRVKKSHKSK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	141/484 (29%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	121/438 (28%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	158/523 (30%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	95/246 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840623
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690