DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt49C1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	190/538 - (35%)
Similarity:	307/538 - (57%)	Gaps:	39/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLL-TLPASMQAA---RILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV 64
            |..|.||. ||.:.::.|   :|||::.|||.|.::.....::||...|||||.|.||..:|..:
  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQL 69

  Fly    65 --NFRDVFIPDVFNNYKEL-INELSGPMNLWQENNFINKFFVSV--------TRCVLTNKEVTET 118
              |:.::.|..|::.:.:: :|  .|..:|::.....|..|:.:        |...|...:|...
  Fly    70 GSNYTEILIEPVYDFWHDVKLN--FGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSL 132

  Fly   119 LLPPGKDH-FDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGG 182
            :....|:. |||::.|....:|:...|..:..|::..||.|.:.::..::|..:|.|:.|.....
  Fly   133 IHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMP 197

  Fly   183 LTDRMTFLERLSN----FVDTTVAWLNYRFVHMSEQEKMYAKYF-PEASKRVQLTDLNRNFSLVL 242
            .||||:||||:.|    |.:.....|||    ..:.:.:..::| |..::..::..:.|..|::|
  Fly   198 FTDRMSFLERVKNSYASFYEDMDRLLNY----FPKMDAVAREFFGPVLTEVPKVKHMERQISVML 258

  Fly   243 LNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPAD 307
            ||.|..|:..||.|..|:.|||:|| :.|.|||.|::..:.|:.| |.|:|||||||.|||:|.:
  Fly   259 LNSHAPLTTARPTVDAMVPVGGMHI-YPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVE 321

  Fly   308 RKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESI 372
            ...|.|:.|.||.|||||||||:.:...|.||.:.||.||.|||||..||:|||||||..|.|.:
  Fly   322 MLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGV 386

  Fly   373 HHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERY 437
            |:..|:||:||:.||.||:.:|...|:.:.|...::|::.|:.:::.|:....:.:..:::|:.:
  Fly   387 HYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIF 451

  Fly   438 RDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIG----VLLGGALLLVAIIVG 498
            ||:|:.|..:|::|.|||:||:||.|||.||.||.:|.::.||||.    :.|.|.:.| ::.:.
  Fly   452 RDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMAL-SLAIR 515

  Fly   499 VLGKLTDFGNAKKKLKSK 516
            :|     .|:.||..|:|
  Fly   516 LL-----MGSNKKHRKAK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	169/478 (35%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	146/428 (34%)
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	175/489 (36%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	168/468 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454708
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790