DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt37A1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	185/526 - (35%)
Similarity:	274/526 - (52%)	Gaps:	38/526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPA-SMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVFIP 72
            |.|||.. ..|.|.||.:||...||..|..:...|.||.:||.||.|...   :|.:..:::.:.
  Fly    13 LALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVL---EPTITHKNINLV 74

  Fly    73 DVFNNYKELINELSGPMNLWQENNFINKFFVSVTRC-------------VLTNKEVTETLLPPGK 124
            .| ...||.|.:.|..:...|:|...|: |:|:...             ||.::.|.|..|  .|
  Fly    75 TV-PMTKEEIKQRSETIGAKQKNTSSNR-FISILNMSGQMDSMLRKMADVLKDQRVKELYL--NK 135

  Fly   125 D-HFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRMT 188
            | ||||:|.....:|...|||...|||::.::.......:::|:||  |........|     ||
  Fly   136 DNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGN--PHDKVEKEKG-----MT 193

  Fly   189 FLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFP- 252
            |.:||.:::.:.:..:..|.:....:: .|.:.|.:.....:.||:.||.|||....|.:...|
  Fly   194 FGQRLDSYISSLLYGIFLRQIDQRNRQ-YYNEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPI 257

  Fly   253 RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFA 317
            ||.||..||:||:.|..||.||||:||:|: |:..||.|..||||||....:.||....|....:
  Fly   258 RPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHIKADTVKKIFSVLS 321

  Fly   318 SLPQRVLWKFED-DKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGL 381
            :|.|||:||::| ||.|||..|:..|:|.||.||||||.|||||.|.|.....|:.:||||:|.|
  Fly   322 NLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSL 386

  Fly   382 PFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLD 446
            |.|.||..|.....::||||.|...|:.::..:..:..:|..|:::|...:.|..|||:|.|..:
  Fly   387 PVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARE 451

  Fly   447 TAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDV---IGVLLGGALLLVAIIVGVLGK--LTDF 506
            :.|:|||||:||.||.|::.....:.|.|.::||:   ||.:..|.||::..:|.:..:  .|..
  Fly   452 SLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKL 516

  Fly   507 GNAKKK 512
            ...||:
  Fly   517 NKVKKQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	172/473 (36%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	148/427 (35%)
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	157/446 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445725
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940