DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt36D1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	174/525 - (33%)
Similarity:	275/525 - (52%)	Gaps:	57/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLALRIGFLLLTLPAS-----MQAA---RILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAF 57
            |.:.|:..|.|.|..|     ::||   ::|.:||.||.|.:....|.:|.||..||.|:.|:.|
  Fly     1 MWSPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHF 65

  Fly    58 PQKKPVVNFRDVFIPDVFNNYKELINELSGPMNLWQENNF---INKFFV----SVTRCVLT--NK 113
            |.|.||.:::|  .|  .....:|.|.:.  :..:::..|   ..:||:    ....|.||  ::
  Fly    66 PDKHPVAHYKD--FP--LTGMDKLTNSVD--LKFFEKRTFYSHFQEFFLLYDWGKQTCNLTLRSE 124

  Fly   114 EVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGIST-FGTDWNIDALVGNESPL--SY 175
            .:.:.|..||:  ||:||:|...:|...|.|....||:|.:|: ....|:.:.:   .:||  |:
  Fly   125 ALQQILRRPGR--FDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERM---GAPLIPSH 184

  Fly   176 TPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQ---------L 231
            .|......:..|.|..||:|:..|..  ||:.:..:|         .|.|...||         :
  Fly   185 IPALFMAQSQHMNFGGRLANWFSTHA--LNWMYKLLS---------VPAADAMVQYKFGHDVPSV 238

  Fly   232 TDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLG 296
            .:|.:|.|:..:|||:|||.|:...||:||:||:|| .|..|||.||:..:. :.|.|||..|.|
  Fly   239 GELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHI-QKSKPLPADLQRILD-NAEEGVILISWG 301

  Fly   297 SNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFIT 361
            |.:.:..|.|.::|.|::..|.|.|:|:||:|::.||.:|.|:.|.||.||.|||.||.||:|::
  Fly   302 SMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMS 366

  Fly   362 HGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRF 426
            ||||:.|.|:.:.|.||:..|.:.|||:|.....:.|.|..|:...:.:..:...::..| :.:|
  Fly   367 HGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKF 430

  Fly   427 AQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALL 491
            ...|:.:|..:..:|...|.|||||.|:|....||..::.:..::..|.|:||||..||   ||:
  Fly   431 HDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVL---ALV 492

  Fly   492 LVAII 496
            |.:||
  Fly   493 LGSII 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	159/486 (33%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	141/432 (33%)
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	157/485 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454593
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100631at6960
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.900