DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	174/568 - (30%)
Similarity:	265/568 - (46%)	Gaps:	108/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LALRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNF 66
            |.|..||        .||.|:|.: |..| |.:..:...:::|::|||:|.
  Rat    16 LFLASGF--------AQAGRLLVV-PMDG-SHWFTMQMIVEKLSHRGHEVV-------------- 56

  Fly    67 RDVFIPDV-FNNYKEL---INELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTE------TLLP 121
              |.||:| ::..|.|   :...|....| ::.|:..|||..       |:..|:      .|..
  Rat    57 --VVIPEVSWHMGKSLNFTVKTYSVSYTL-EDLNYHFKFFAH-------NQWKTQEVGMFSLLKH 111

  Fly   122 PGKDHFDLI------------IVEALRSDAYYG------------FAAHFNAPIIGISTFGTDWN 162
            .||..|:|:            :||.|:..::..            .|.:|:.|.:..|.......
  Rat   112 SGKGFFELLFSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLILAKYFSLPSVVFSGGIFCHY 176

  Fly   163 IDALVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMS-EQEKMYAKYFPE-- 224
            :|......||.||.|......||.|||.||:.|              |:| .:|:.:..||.:
  Rat   177 LDEGAQCPSPPSYVPRILSKFTDTMTFKERVWN--------------HLSYMKERAFCPYFFKTA 227

  Fly   225 ---ASKRVQ----LTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFI 282
               ||:.:|    :.||....|:.:....|.|.||||.:|||:.:||:: .|:..||.|:.|.::
  Rat   228 VEIASEVLQTPVTMRDLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGIN-CHQGKPLSKEFEAYV 291

  Fly   283 QGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQ 347
            ..|||||::.|||||.|  .::|..:...|.:....:||.|||::...:......|..:.||.||
  Rat   292 NASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQ 354

  Fly   348 PDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQE 412
            .|:|.|||.:.||||.|.....|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:
  Rat   355 NDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADD 419

  Fly   413 LKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYH 477
            |:..::.::....:.:...::|..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||
  Rat   420 LENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYH 484

  Fly   478 SLDVIGVLLGGALLLVAIIVGVL---------GKLTDFGNAKKKLKSK 516
            ||||||.||...|.:|.|:....         ||    |..||..|||
  Rat   485 SLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGK----GRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	146/501 (29%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	125/455 (27%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	163/541 (30%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	95/243 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860