DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_038959826.1	Gene:	Ugt3a2 / 294793	RGDID:	1564365	Length:	454	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	146/494 - (29%)
Similarity:	230/494 - (46%)	Gaps:	71/494 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ELANRGHQVT--SVNAFPQKKPV--VNFRDVFIPDVFNNYKELINEL---SGPMNLWQENNFINK 100
            |.::.|:::.  .|:..|||..:  :.|....|..:..::.:|.|.|   ...|...:..||...
  Rat     8 EKSHPGNRIMHYRVDLCPQKVKLNKLQFEHHTIVKIHRHFGDLCNHLLSRKDIMEFLKNANFDLV 72

  Fly   101 FFVSVTRCVLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDA 165
            .|.||..|   :..:.|.|   || .|.|.:...|      ||               .|:.:..
  Rat    73 LFESVDYC---SSLIVEKL---GK-QFVLFLAFQL------GF---------------MDFELQR 109

  Fly   166 LVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMS-EQEKMYAKY-------F 222
            :     ||||.|:...||||:|.|..|:.||:         .|..:| :|.::.::|       |
  Rat   110 V-----PLSYVPVYGSGLTDQMDFWGRVKNFL---------MFFDLSRKQREILSQYDSTIQEHF 160

  Fly   223 PEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSG 286
            .|.|:.| |:||.....|..:|..|:..|.||..||::.||||  ..||. .:|:|||.||...|
  Rat   161 AEGSRPV-LSDLLLKAELWFVNCDFAFEFARPLFPNIVYVGGL--LDKPVQSIPQDLENFITQFG 222

  Fly   287 EHGVIYFSLGSNVLSKDLPADRKDLILK---TFASLPQRVLWKFEDDKLPGKPS---NVFISKWF 345
            :.|.:..:||: |.:|   ...|::|.:   .||.|||.|:|..:|...|...:   ||.|..|.
  Rat   223 DSGFVLVALGT-VATK---FQTKEIIKEMNNAFAHLPQGVIWACKDSHWPKDVTLAPNVKIMDWL 283

  Fly   346 PQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQ 410
            ||.|:||||.::||:||||:.|..|:|.||.|::|:.||.||..|:.|......|:.:...|:..
  Rat   284 PQTDLLAHPSIRLFVTHGGMNSVNEAIQHGVPMVGILFFSDQPENMIRVEAKTIGVSIQIQTLKA 348

  Fly   411 QELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFA 475
            :....|::.::::.|:...|..........|::|......|.:::|:..||.|::.......:..
  Rat   349 ETFARTMKEVIEDKRYKSAAMASKIIRHSHPLTPSQRLEGWIDHILQTGGAAHLKPYAFQQPWHE 413

  Fly   476 YHSLDVIGVLLGGALLLVAIIVGVLGKLTDFGNAKKKLK 514
            .:.|||...|||..|..|.:.|.|||.:..:.:..:|.|
  Rat   414 QYLLDVFLFLLGLTLGTVWLCVKVLGAVMRYLSGARKAK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	132/444 (30%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	125/416 (30%)
Ugt3a2	XP_038959826.1	Glycosyltransferase_GTB-type	49..419	CDD:415824	125/418 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830