DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	178/544 - (32%)
Similarity:	284/544 - (52%)	Gaps:	61/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLTLPASMQAARILAIFPFPGP-SQYINVVPYLKELANRGHQVT------SVNAFPQKKPVVN 65
            |||:.|....:......:..:|.. |.:||:...|.|||.|||:||      |:...|.|:..:|
  Rat     9 FLLIQLICYFRPGACGKVLVWPTEYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKESSIN 73

  Fly    66 FRDVFIP----DVFNNYKELINELS---GPMNLWQENNFINKFF-------VSVTRCVLTNKEVT 116
            |....:|    |:..::.:.|:|.:   ..:::|...:.:.|.|       .::.:.::.||.:.
  Rat    74 FEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVVENLCKALIWNKSLM 138

  Fly   117 ETLLPPGKDHFDLIIVEALRSDAYYG-----FAAHFNAPIIGISTFGTDWNIDALVGN-ESPLSY 175
            :.|   ....||:|:.:|:      |     .|.....|::....|...:..:...|. ..|.||
  Rat   139 KKL---QGSQFDVILADAV------GPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGLPLPPSY 194

  Fly   176 TPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKR-VQLTDLNRNFS 239
            .|:....|:|||||:||:.|.:.    .|.:.|.....:||.:::::.:...| ..||::.....
  Rat   195 VPVVLSELSDRMTFVERVKNMLQ----MLYFDFWFQPFKEKSWSQFYSDVLGRPTTLTEMMGKAD 255

  Fly   240 LVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLSKD 303
            :.|:...:.|.||.|::||...|||||.  ||| |||:::|||:|.||||||:.|||||.|  |:
  Rat   256 IWLIRTFWDLEFPHPFLPNFDFVGGLHC--KPAKPLPREMEEFVQSSGEHGVVVFSLGSMV--KN 316

  Fly   304 LPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLST 368
            |..::.:::....|.:||:|:|:|:..|.....||..:.||.||.|:|.|||.|.|:.|||....
  Rat   317 LTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGGTNGI 381

  Fly   369 IESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQM 433
            .|:|:||.|::|:|.|.||..|:......|..:.:|.:.::...|...::|::.:|.:.:.|.::
  Rat   382 YEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMRL 446

  Fly   434 SERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVG 498
            |..:.|||:.|||.|::|.|||:|||||.|:|....||.:|.||||||||.||       ..:||
  Rat   447 SRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLL-------LCVVG 504

  Fly   499 VLGKLTDF--------GNAKKKLK 514
            |:..:|.|        .|..||.|
  Rat   505 VVFIITKFCLFCCRKTANMGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	155/486 (32%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	134/440 (30%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	172/526 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760