DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	174/537 - (32%)
Similarity:	278/537 - (51%)	Gaps:	45/537 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGP-SQYINVVPYLKELANRGHQVTSV--NAF----PQKKPVVNF 66
            |||.:....|:.....:..:|.. |.::|:...|.||..|||:||.:  :|:    |:|.|.:.|
  Rat    10 LLLQISCCFQSGNCGKVLVWPMEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDLKF 74

  Fly    67 RDVFIPDVFNNYKELINELSGPMNLWQE--------------NNFINKF---FVSVTRCVLTNKE 114
             :.|...|..:  ||.|.....:::|..              .|.|:.|   ::|:.:..::||:
  Rat    75 -ETFPTSVSKD--ELENYFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQ 136

  Fly   115 VTETLLPPGKDHFDLIIVEALRSDAYYG--FAAHFNAPIIGISTFGTDWNIDALVGN-ESPLSYT 176
            :...|   .:..||:::.:.:   |..|  .|...:.|.:....|...:.|:...|. ..|.||.
  Rat   137 LMAKL---QESKFDVLLSDPV---AACGELIAEVLHIPFLYSLRFSPGYKIEKSSGRFILPPSYV 195

  Fly   177 PLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLV 241
            |:...|:...|||::|:.|.:.|  .:.::.| ||...:|....|.....:...|.:......:.
  Rat   196 PVILSGMGGPMTFIDRVKNMICT--LYFDFWF-HMFNAKKWDPFYSEILGRPTTLAETMGKAEMW 257

  Fly   242 LLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPA 306
            |:..::.|.||.|.:||:..:|||. ...|.|||||:|:|:|.||||||:.|||||.|.|  :..
  Rat   258 LIRSYWDLEFPHPTLPNVDYIGGLQ-CRPPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSS--MTE 319

  Fly   307 DRKDLILKTFASLPQRVLWKFEDDKLPGK-PSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIE 370
            ::.:.|....|.:||:||||| |.|.|.. ..|..:.||.||.|:|.|||.|.|:||||.....|
  Rat   320 EKANAIAWALAQIPQKVLWKF-DGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYE 383

  Fly   371 SIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSE 435
            :|:||.|::|:|.|.:|..|:......|..:.|:..||::.:|...::.::..|.:.:.|..:|.
  Rat   384 AIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLST 448

  Fly   436 RYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLG-GALLLVAIIVGV 499
            .:.||||.|||.|::|.|:|:|||||.|:|..|.:|.::.||||||||.||. .|::.|..:...
  Rat   449 IHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVIAVLTVKSF 513

  Fly   500 LGKLTDFGNAKKKLKSK 516
            |.....|...:||:|::
  Rat   514 LFIYRLFVKKEKKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	154/484 (32%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	133/439 (30%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	168/518 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344075
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690