DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	550	Identity:	162/550 - (29%)
Similarity:	267/550 - (48%)	Gaps:	72/550 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GFLLL--TLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQ----VTSVNAFPQKKPVVN 65
            |.|||  .||.: :.|::| :.|..| ||::::...::||..||||    .:.|....:.:....
Mouse    14 GLLLLLCALPWA-EGAKVL-VLPMEG-SQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFT 75

  Fly    66 FRDVFIPDVFNNYKELINELSGPMNLWQENNFINKFFVSV-----------TRCV--LTNKEVTE 117
            .:....|.....|::.|  ||.....::..:|:..||.:.           ..|:  |.||.:.:
Mouse    76 LKTYAFPYTKEEYQQEI--LSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQ 138

  Fly   118 TLLPPGKDHFDLIIVEALRSDAYYGF------AAHFNAPIIGI---STFGTDWNIDALVGNESPL 173
            .|   ....||:|:.:.:       |      |.:...|.:.|   .:.|.::.....   .:|.
Mouse   139 QL---NSSFFDVILTDPI-------FPCGAVLAKYLQIPAVFILRSLSCGIEYEATQC---PNPS 190

  Fly   174 SYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFV---HMSEQEKMYAKYFPEASKRVQLTDLN 235
            ||.|.....|:|.|.||:|:.|.    :.:|..:::   .::..|.:.::..   .:.|.|.::.
Mouse   191 SYIPNLLTRLSDHMDFLQRVQNM----LYYLVLKYICRLSITPYESLASELL---QREVSLVEVL 248

  Fly   236 RNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVL 300
            .:.|:.|....|.|.:|||.:|||:.:||::...| .||.::.|.::..|||||::.|||||.|
Mouse   249 SHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTK-KPLSQEFEAYVNASGEHGIVVFSLGSMV- 311

  Fly   301 SKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGL 365
             .::|..:...|.:....:||.|||::...:......|..:.||.||.|:|.|||.:.||||.|.
Mouse   312 -SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGS 375

  Fly   366 LSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIA 430
            ....|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:|:..::.::....:.:..
Mouse   376 HGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENI 440

  Fly   431 RQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAI 495
            .::|..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||||||||.||...|.:|.|
Mouse   441 MRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFI 505

  Fly   496 IVGVL---------GKLTDFGNAKKKLKSK 516
            :....         ||    |..||..|||
Mouse   506 VFKCCAYGCRKCFGGK----GRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	136/488 (28%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	113/440 (26%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	151/526 (29%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	27/143 (19%)
		egt	<261..505	CDD:223071	95/246 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840622
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690