DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt-42

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_503278.2	Gene:	ugt-42 / 185168	WormBaseID:	WBGene00017959	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	113/544 - (20%)
Similarity:	212/544 - (38%)	Gaps:	74/544 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFR- 67
            |.|..:.:.|.:::.....|.:.|..|.|....:......|...||.||.::.....|    ||
Worm     3 LLILLIFVFLISNISGFNYLVVSPAFGHSHSTFMGKLADALTEAGHNVTVLSIIVSSK----FRN 63

  Fly    68 --------DVFIPDVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPG- 123
                    |:.:.:..|...:....:        |||..::::..       ...:.||:  |.
Worm    64 ISYTKLTKDIVVVETTNEQDQQAENM--------ENNDFSRYWTQ-------EGTLLETI--PSY 111

  Fly   124 ------KDH-FDLIIVEAL-----------RSDAYY---------GFAAHFNAPI-IGISTFGTD 160
                  .|| ::.....||           |.||.:         ....:...|: :.:::...|
Worm   112 LMFTKMSDHGYETFRNHALPQMEYLKSHRPRYDAVFFESYLHTGKAIQEYLEIPVFLPVTSLTHD 176

  Fly   161 WNIDALVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEA 225
            :.:..|:|.       |::...|:...|....:.||.:..:..|:|....:......: |...:.
Worm   177 YRLAELIGE-------PVSPSYLSGYFTNFGNIMNFQERVINTLSYYLAQILISSPNW-KTLQDP 233

  Fly   226 SKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEF--IQGSGEH 288
            ||.:.:.........|.:|.:..:.||||.:...||:||:.:........|..|.:  |.....|
Worm   234 SKDLLVESEYYRAPYVFINSNPYIDFPRPLLSKTIEIGGITVDADALKSEKVDETWNNILKRRPH 298

  Fly   289 GVIYFSLGSNVLSKDLPADRKDLILKTFASLPQ-RVLWKFEDDK--LPGKPSNVFISKWFPQPDI 350
            .|: .|.|:...|..:|...|:.::|...|... ..:||:|.::  ......|:...||.||..:
Worm   299 NVL-ISFGTMFKSIHMPDSYKNNMVKVMKSFKNVTFIWKYESEETSFANGAENIIFKKWTPQTAL 362

  Fly   351 LAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTM-TQQELK 414
            ||..::..|.|||||.|..|..:.|||.|..|.|.||..|.:..::....:.:....: :...|:
Worm   363 LADSRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQVRNSKMLSRHNGSIEISKFNLESYNTLR 427

  Fly   415 ETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSL 479
            ..:..:|.:..:|:.|.:::::...||..|.:..:...|:..|......:....:.:||..||.|
Worm   428 SALHSILFDESYAENAEKLAKKLEFQPAKPKELFVRHAEFAARFGEQPALDCNLRTMGFATYHLL 492

  Fly   480 DVIGVLLGGALLLVAIIVGVLGKL 503
            ||:..|....:|::..:|.::.|:
Worm   493 DVVVCLTSFVVLVILSLVVIIRKI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	100/501 (20%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	93/455 (20%)
ugt-42	NP_503278.2	Glycosyltransferase_GTB_type	14..501	CDD:299143	107/516 (21%)
ugt-42	NP_503278.2	UDPGT	22..495	CDD:278624	105/502 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810