DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt-38

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_504812.1	Gene:	ugt-38 / 184294	WormBaseID:	WBGene00017333	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	125/548 - (22%)
Similarity:	218/548 - (39%)	Gaps:	76/548 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV-----NF-- 66
            ||.||.|::.:...|...|....|...........|.:.||.|....      |::     ||
Worm     6 LLFTLYANVSSFNFLVFCPLFAHSHSKFFATIADSLTDAGHNVAFFT------PIIVEKYRNFNY 64

  Fly    67 ----RDVFIPDVFNNYKELINELSGP--MNLWQENNFINKFFVSVTRCV--LTNKEVT------E 117
                :||...:.....||...::|..  :..|.|::...: .::|.|..  :.|::.|      |
Worm    65 TKSTKDVVYMEPSKKLKEYGRQMSTGDFVRYWTEDSTATE-IITVVRIFQKMYNEQGTVMKDNIE 128

  Fly   118 TLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPI---IGISTF------GTDWNIDALVGNESPL 173
            .|....|..||:||.||....||         |:   :.|.||      ..|..:...:|.....
Worm   129 ILNDLKKRKFDVIIFEAFIFSAY---------PLMDYLEIPTFIPSLSVAHDTALAVEIGEPVMP 184

  Fly   174 SYTPLATGGLTDRMTFLERLSN-----FVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTD 233
            |..........|:::..||..|     :.|..:.:..:|        .....|.|     :.:..
Worm   185 SVVSDCLSPFGDKLSITERAFNAFMVPYFDFMIGYPTHR--------SFKPPYNP-----IDIRS 236

  Fly   234 LNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISH---KPAPLPKDLEEFIQGSGEHGVIYFSL 295
            :....|.|.||.:..:.||||.:...|::||:.:..   :...|.:...|.::  .....:..|.
Worm   237 IVPEASFVFLNSNPFVDFPRPTLTKTIQIGGISVDSNELRSQKLDETWSEILK--LREKTMLVSF 299

  Fly   296 GSNVLSKDLPADRKDLILKTFASLPQRV--LWKFED---DKLPGKPSNVFISKWFPQPDILAHPK 355
            ||.:.|||:|...| :.||......:.|  :||:||   |:......|:..:||.||..:||..:
Worm   300 GSMLYSKDMPFKNK-IALKNAMEKFKNVTFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLADSR 363

  Fly   356 VKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQE-LKETIEI 419
            :..|:||.||.|..|..:.|||.:..|..:||..|.:...:....:.|....:.:.| :.|..:.
Worm   364 LSAFLTHAGLGSITELSYLGKPAILCPQLFDQMRNTKMLVRHNGSIELSKYDLGKSEKIIEAFQA 428

  Fly   420 LLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGV 484
            :|.:..:|:.|::::|:..:||:.|.:..:...||..|......:....:.:.|..|..|||..:
Worm   429 ILFDSSYAKNAQKLAEQLENQPIKPKEMMVKHAEYAARFGRLPSLDPYSRKMSFVEYFLLDVAAI 493

  Fly   485 LLGGALLLVAIIVGVLGKLTDFGNAKKK 512
            .:.....:|.::..::..|.|....|:|
Worm   494 CVFILTFVVFVVTKLVQSLFDIFLIKRK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	115/500 (23%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	103/455 (23%)
ugt-38	NP_504812.1	Glycosyltransferase_GTB_type	12..512	CDD:299143	117/531 (22%)
ugt-38	NP_504812.1	UDPGT	29..521	CDD:278624	117/523 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810