DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt-65

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_502373.3	Gene:	ugt-65 / 184205	WormBaseID:	WBGene00008583	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	131/543 - (24%)
Similarity:	230/543 - (42%)	Gaps:	86/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT----SVN--AFPQKKP 62
            :.|.|||.....:...:|||.:..|...|..:.::|..:.|.:.||.|:    |.|  ..|.||.
Worm     8 ITIIFLLAHFLTTSNCSRILFLNMFNSKSHALTMMPLAERLFDDGHDVSMYTISANRLKIPSKKV 72

  Fly    63 VV-------NFRDVFIPD------VFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKE 114
            .:       :..|...||      :|.:|     |::..:..|...  |..:::...|    :::
Worm    73 KILESLVKGSSTDDAAPDTGGVSRIFWSY-----EMTPYVGAWCYE--IGLYYLEEGR----DEQ 126

  Fly   115 VTETLLPPGKDHFDLIIVE----ALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSY 175
            :.|.|..|    :||.:|:    :|:...........:..||   ||.|. .:..:..|....:.
Worm   127 LDEVLATP----YDLAVVDETYTSLQGSIALKLKEDHSTKII---TFATT-ELMPVASNMRGYAR 183

  Fly   176 TPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMY------------AKYFPEAS-K 227
            .|     :|...|||  ||:.|     :...||..::...:::            |..:.||| |
Worm   184 NP-----VTVPNTFL--LSSEV-----YEGNRFAFLTRTRRIFEYFIDQIYSGPVASLYSEASGK 236

  Fly   228 RVQLTDLNRN----FSLVLLNQH-FSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGE 287
            .:.||...::    .|::.:|.. .:.||.:|...::|.||  ...:..|.||.:..:|::.|..
Worm   237 LLGLTSATKSKTFQNSILTVNDFPDTFSFVQPRGNDLIRVG--EHCYSSANLPSEFRDFVEDSMS 299

  Fly   288 HGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQ-RVLWKFEDDKLPGKPSNVFISKWFPQPDIL 351
            .|.||.::||.:..:|.|....:..::....... ||:|..:.: :.|...:|....|.||.::|
Worm   300 KGTIYVAMGSYLNLEDGPKGTVEAFIEALNYFKDYRVIWSHKGN-VTGAKCHVKSVNWAPQKELL 363

  Fly   352 AHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKET 416
            ||.|...|||||||.|..|.:..|.|:|.|||:.||..|..|....|....|....:|..::::.
Worm   364 AHEKTVAFITHGGLKSAKEGVCSGVPMLFLPFYGDQPRNAHRFVTNGIAEALYKKAITSLDIQQK 428

  Fly   417 IEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQD--LGFFAYHSL 479
            :|.||.:|.:.....::...|.|.|:|.||...:....|||...:.:.:...:.  :....|.:|
Worm   429 LEKLLVDPSYKNNVMKVLSYYLDAPISSLDLGAFHISQVLRRTESQYSKFKRRSIFMNHLQYLNL 493

  Fly   480 DVIGVLLGGALLLVAIIVGVLGK 502
            |:        .|::.:|:.::.|
Worm   494 DI--------FLVILVILFIVSK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	124/499 (25%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	109/453 (24%)
ugt-65	NP_502373.3	egt	<300..505	CDD:223071	59/213 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010