DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt-43

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001255487.1	Gene:	ugt-43 / 184052	WormBaseID:	WBGene00008485	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	130/540 - (24%)
Similarity:	223/540 - (41%)	Gaps:	94/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLTLPA-------SMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVN 65
            ||||.|.:       :::..::|...|..|.|....:......|...|:.||.:      .|:::
Worm     8 FLLLILASFCFSVSNNIKGKKVLVYLPVTGHSHLKFMSTTSNILQEEGYNVTLL------LPLID 66

  Fly    66 FRDVFIPDVFNNYK-ELINELSGPMNLWQENNFINKFFVSVTRCV-----LTNKEVTETLLPPGK 124
            .       ..||.. .::.::...:||        .....|.|.:     :.::..|.|:   |.
Worm    67 I-------TLNNTNIPIVKKIKHRINL--------DIHPGVMRTIIKMGGMASRRQTWTM---GS 113

  Fly   125 DHFDLIIVEALRSDAYYGFAAH-FNAP--------------------IIGISTF---GTD--WNI 163
            ..:....:..|.||.|.....: |:.|                    :.|.:.|   |.|  .::
Worm   114 GIYGFDGISHLLSDLYSNICDNIFHMPGLLDRLKAEKYEMGMSEPFFVCGFALFDHLGIDKIISV 178

  Fly   164 DALVGNESP---------LSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRF---VHMSEQEK 216
            |:.:|.|.|         .||.|.|....:|.|:|:||..:..:|   :||.:|   :|..|.:.
Worm   179 DSHIGLEGPKIAHGFPVTSSYLPAAFSESSDHMSFVERTRSLYET---YLNRKFARLIHNKEIDA 240

  Fly   217 MYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHK--PAPLPKDLE 279
            |...|..:::    ..:|.|..:.:..|.:..|.||.|.....||:||:....|  ...||:..:
Worm   241 MKGVYKGKST----WEELMRLPAYMFTNSNPILDFPYPRPSKFIEIGGIAADEKKHDEVLPESYD 301

  Fly   280 EFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQ-RVLWKFEDDKL----PGKPS-- 337
            ..:  :..:..:..|.|||..|..:|...:..::.....:|. ..:||:|:..:    ...|:
Worm   302 HIL--NLRNRTVLISFGSNAKSIFMPDHMRRSLIIALGMMPDITFIWKYENSSIDIVKEFDPTIK 364

  Fly   338 NVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLG 402
            |:....|.||..:||.|::.||:||||:.||.|....|||.:.:|.|.||..|.|...:.|..|.
Worm   365 NIVQVDWMPQQALLADPRLDLFVTHGGMASTNEIAFSGKPAVMVPVFGDQTRNSRMLERHGGVLM 429

  Fly   403 LDHTTMTQQELK-ETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRV 466
            |....:...|:. |||..:|.:|.:|:.|:|::...|:.|.||....:.:..:|.|......:..
Worm   430 LRKENLEYPEIVIETILSVLNDPSYAERAQQLATLLRNHPESPKQVFLKYFNFVARFGKPTGIDS 494

  Fly   467 AGQDLGFFAYHSLDVIGVLL 486
            ...::.|.||:.||:|..||
Worm   495 NSINVDFIAYYYLDLIAFLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	122/518 (24%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	110/465 (24%)
ugt-43	NP_001255487.1	Glycosyltransferase_GTB_type	<215..517	CDD:299143	86/309 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810