DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt-2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_505672.2	Gene:	ugt-2 / 179450	WormBaseID:	WBGene00007073	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	141/546 - (25%)
Similarity:	239/546 - (43%)	Gaps:	63/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLTLPASMQAARILAIFPFPGPS--QYINVVPYLKELANRGHQVTSVNAFPQ----KKPVVNF 66
            ||...|..::.|...|.:.|..|.|  :::|.|  ...|||..|.||.:..:..    |..:|..
Worm     8 FLFFALYCNVLAYNYLVVAPVFGYSHMKFMNKV--ADTLANGKHNVTLLQTYIYEHWGKIRIVKN 70

  Fly    67 RDVFIPDVFNNYKELINELS-GPMNLWQENNFINK--------FFVSVTR----C--VLTNKEVT 116
            :::.|.|..|:.....||.| .....:.:|..:|.        .|:....    |  :||:||:.
Worm    71 KNIEIIDYHNSENVPSNEQSASAFKFFWDNEIVNNPITGAMAPMFILYNEFKPMCDRILTDKELH 135

  Fly   117 ETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDA--LVGNESPLSYTPLA 179
            :.:|   .:.||..:.|:....:.| ...|....::.:  |.|..|:..  .:|..|.|:|.|..
Worm   136 QWIL---SNKFDGYVAESFDFCSLY-LGDHLKLNLLPM--FSTIKNVPGSHAIGEPSLLNYAPSL 194

  Fly   180 TGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQL-TDLNRNFSLVLL 243
            ........|..:|:.:.  |.....:|.|.::.|::  |.:.:...:..|:. .::.:..:....
Worm   195 YTNFGSDQTVWDRIQDI--TAFTSFHYAFSNLFERQ--YRQAYDLLNGDVRTWREILQTATYFFY 255

  Fly   244 NQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDL---EEF-----IQGSGEHGVIYFSLGSNVL 300
            |.:..:.|..|.:...:|:||..|..     |.||   |||     ::.|    .:..|.|:.|.
Worm   256 NNNPYIGFAMPTLEKSVEIGGFTIDP-----PHDLSLNEEFDKLLDLRKS----TVLISFGTVVQ 311

  Fly   301 SKDLPADRKDLILKTFASLPQRV-LWKFE-DDKLPGK--PSNVFISKWFPQPDILAHPKVKLFIT 361
            |.|:|.:.|..::|.||.||... :||:| :|....|  ..|||:.||.|||.:||.|::.||||
Worm   312 SADMPENFKSGLIKMFAKLPDTTFIWKYEVEDAEFSKTLSENVFLKKWIPQPALLADPRLNLFIT 376

  Fly   362 HGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQE-LKETIEILLKEPR 425
            ||||.||:|..:.|||.|.:|.|.||.||.:..::.|..:..|...:...| |.||::..:....
Worm   377 HGGLGSTLEVAYAGKPSLMIPIFGDQMLNAKMLSRHGGAISYDKYELENYEKLTETVKEAISNKE 441

  Fly   426 FAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGAL 490
            :.:.|..::|...:||:.|....:...|:..:....:.:........|..|:.||...::    :
Worm   442 YNKKALLLAEILHNQPIDPKQNLLKHAEFTAKFGRVHALEPYSVHYNFIKYYMLDAYAII----I 502

  Fly   491 LLVAIIVGVLGKLTDFGNAKKKLKSK 516
            :....|:.||..:..| ..:|..|||
Worm   503 IFFLSILYVLNLIIKF-VYRKIFKSK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	129/494 (26%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	120/448 (27%)
ugt-2	NP_505672.2	egt	15..498	CDD:223071	130/503 (26%)
ugt-2	NP_505672.2	UDPGT	31..530	CDD:278624	134/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810