DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	143/523 - (27%)
Similarity:	224/523 - (42%)	Gaps:	64/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVFIP 72
            ||||:|.| :.|.:||...|....|..|:.......|.:.||.|  |....:.:|:..|.
Worm     6 FLLLSLLA-VDAGKILVYSPSISRSHLISNGRIADALVDAGHDV--VMFITEYEPLTEFT----- 62

  Fly    73 DVFNNYKELINELSGPMNLWQEN-NFINKFFVSVTR----------------C--VLTNKEVTET 118
               ...|..:..:.|....:.|: :.|.::.:|.:|                |  ::|.:|..|.
Worm    63 ---GTKKAKVITMKGFSTKFAEDMDGIGEYLLSSSRLSFLERLMFEKTCTGACDDLMTRREELEQ 124

  Fly   119 LLPPGKD-----HFDLIIVEALRSDAYYGFAAHF---NAPIIGISTFGTDWNIDALVGNESPLSY 175
            |.....|     ..||..|..:|   |.|...|.   ..||:...::.        :|..:|.||
Worm   125 LRAYNFDVAFSEQIDLCGVGIVR---YLGIKNHLWISTTPIMDAVSYN--------LGIPAPSSY 178

  Fly   176 TP-LATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFS 239
            .| :......|:|.|.:|..|......:.|.:|:......| ::.||.|:..   .:.::..|.|
Worm   179 VPTIEENDNGDKMDFWQRTFNLYMKIGSILIHRYGTDGTTE-VFRKYIPDFP---NVREIAANSS 239

  Fly   240 LVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDL 304
            |..:|....|..|||.:...|.||||.|.....||.|.... |...|:.||:..||||.:...||
Worm   240 LCFVNSDEVLDLPRPTITKAIYVGGLGIPKVSKPLDKKFTN-IMSKGKEGVVIISLGSIIPFGDL 303

  Fly   305 PADRKDLILKTFASLPQ-RVLWKF-----EDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHG 363
            ||..|:.:|:....:.. ..|.|.     ...||.....||.:::|.||.|||:||::|||:.||
Worm   304 PAAAKEGVLRAIQEISDYHFLIKIAKGDNNTKKLVEGIKNVDVAEWLPQVDILSHPRLKLFVMHG 368

  Fly   364 GLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQ 428
            |:...:|:.....|.:.:|.|.|||.|.|...:.|.|..|....:..:..|.|:..:|..|.:.:
Worm   369 GINGLVETAIQAVPTVIVPVFADQFRNGRMVEKRGIGKVLLKLDIGYESFKNTVLTVLNTPSYKK 433

  Fly   429 IARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLV 493
            .|.::.:..||:|.||.:....||::.:.|.....:.|.|..|....|::||||..:|   .:.|
Worm   434 NAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHVEGSRLNTIIYYNLDVIAFVL---FVFV 495

  Fly   494 AII 496
            |::
Worm   496 AVL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	132/491 (27%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	115/445 (26%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	136/511 (27%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	92/314 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710