DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt-11

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	142/540 - (26%)
Similarity:	240/540 - (44%)	Gaps:	68/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AARILAIFPFPGPSQYINVVPYLKE-LANRGHQVTSVNAF----PQKKPVVNFRDV----FIPDV 74
            ||:||...|..|.| ::..|..|.: :|:.|.:||....|    .....:|..:::    :.||
Worm    18 AAKILIFNPIFGFS-HVKFVSKLADIIADHGQEVTLFQPFHLALKNLDGIVKNKNIEIINYYPD- 80

  Fly    75 FNNYKELIN-ELSGPMNLWQE---NN----------FINKFFVSVTRCVLTNKEVTETLLPPGKD 125
              :|.:|:. |.....:.|..   ||          .:...|...|..::.:||:.:.|    ||
Worm    81 --HYDDLLKLETQTFPDFWDSQLMNNPVLMAFMLPRILGGEFKKTTIQLIKDKEILKKL----KD 139

  Fly   126 -HFDLIIVEALRSDAYYGFAAHF-NAPIIGI-STFGTDWNIDALVGNESPLSYTPLATGGLTDRM 187
             .||:.|.|.......|  .:|| ..|.|.| |....|...:|. |..|...|.......|....
Worm   140 KKFDVAISETFELTGMY--MSHFLGVPCIPILSAVRLDIFNEAF-GQSSAFGYLTQQGSKLAPDA 201

  Fly   188 TFLERLSNFVDTTVAWLNYRFVHMSEQ---EKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSL 249
            .||:||::......:.:.:|.:...:.   ||......|      ...||.:...:.:.|.:..|
Worm   202 GFLDRLNDVYRDFFSKMAFRGMAQYQNDVIEKAAGHVVP------YWKDLVKEAPVYMTNSNPYL 260

  Fly   250 SFPRPYVPNMIEVGGLHI-----SHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRK 309
            .|..|....::.:||:.|     :|..| ||::.|..::  .:...:..|.||.:.|.::|.:.|
Worm   261 DFAVPTTATIVHIGGITINLEKMNHVDA-LPEEYEIILK--EKETTVLISFGSVIRSYEMPENFK 322

  Fly   310 DLILKTFASLPQRV-LWKFEDDKLPGK---PSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIE 370
            ..::|.|.|||..: :||:|.|.|..:   |.||.:.||.|||.:||..:||||:|||||.||:|
Worm   323 AGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKNVHLKKWVPQPSLLADKRVKLFVTHGGLGSTME 387

  Fly   371 SIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQ-QELKETIEILLKEPRFAQIARQMS 434
            ..:.|||.|.:|.|.||.:|.....:.|..:..|...:.. ::|.||:..|:..|::.|.|:::.
Worm   388 VAYTGKPALMVPIFGDQPMNADMLARHGGAIAYDKFDLVDGKKLTETVRDLVTNPKYEQKAKELL 452

  Fly   435 ERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLV----AI 495
            :...:||:.|:...:...|:.::.............:|..|::.||||..|:..:::..    .|
Worm   453 DVLTNQPIDPVMNLMKHLEFAIKFPNLRSQIPEINQVGPIAHYYLDVIVFLIFVSIITAYISFQI 517

  Fly   496 IVGVLGKLTDFGNAKKKLKS 515
            :..:|.::     ..||:||
Worm   518 VCRILSRI-----LSKKVKS 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	129/485 (27%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	121/450 (27%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	85/302 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810