DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt-12

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_504309.1	Gene:	ugt-12 / 178880	WormBaseID:	WBGene00020592	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	147/571 - (25%)
Similarity:	243/571 - (42%)	Gaps:	97/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIG---FLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT----------SVN 55
            :|:|   |||..|.....:::||...|..|.|....:......:|:.||.||          :::
Worm     1 MRLGTFIFLLTFLFFECYSSKILIFNPIFGFSHVKFISKMADIIADHGHHVTLFQPYHIALKNLD 65

  Fly    56 AFPQKK--PVVNFRDVFIPDVFNNYKELINELSGPMN---LWQE----NNFINKF---------F 102
            ...:.|  .::|:..       .:|:||:.  :.|..   .|..    |..|..|         |
Worm    66 GLVKNKNIEILNYHP-------THYEELLK--AEPQTFSFFWDSYLVGNPVIGAFLMPKLLGGEF 121

  Fly   103 VSVTRCVLTNKEVTETLLPPGKDH-FDLIIVEALRSDAYYGFAAH-FNAPIIGIST------FGT 159
            ......||:::::...|    ||. |||:|.|......:|  .|| .:.|.|.:.:      |..
Worm   122 KKTAMEVLSDQKLINEL----KDRKFDLVIAETFELTGFY--LAHLLDVPCIPMMSAVRYPIFND 180

  Fly   160 DWNIDALVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHM---SEQEKMYAKY 221
            .:      |..|.|.:.|.....:.....|.:||::.         :||..|   .||...|..|
Worm   181 QF------GQPSLLGHVPQIGSAVAGEAGFYDRLNDM---------FRFFFMGISQEQLNKYQNY 230

  Fly   222 FPEAS--KRVQL-TDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKP----APLPKDLE 279
            |.|.:  :.|.. .||.:...:.:.|.:..|.:..|....:::|||:.:..|.    ..||::.|
Worm   231 FIEEAIGRPVPFWKDLVKQSPIYITNSNPYLDYAVPSTAAIVQVGGITMDLKKLKQVGELPEEYE 295

  Fly   280 EFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQ-RVLWKFEDDKLPGK---PSNVF 340
            ..::  .....:..|.||.:.|.::|...|..::|.|.|||. ..:||:|.|.|..:   |.||.
Worm   296 NILK--ERESTVLISFGSVIRSYEMPESFKAGLIKVFESLPDVTFIWKYEKDDLEFQKRLPKNVH 358

  Fly   341 ISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDH 405
            :.||.|||.:||..:||||||||||.||:|..:.|||.:.:|.|.||..|.....:.|..:..|.
Worm   359 LKKWIPQPSLLADKRVKLFITHGGLGSTMEVAYTGKPAIVVPIFGDQHHNAVMLARHGGAVAYDK 423

  Fly   406 TTMTQ-QELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQ 469
            ..:.. ::|...:..::...::.:.|..:.....:||:.|....:...::.::.........|..
Worm   424 FDLKNGEKLTAVVHEMISSTKYQENAEALQHVLFNQPIDPKMNFLNHLDFAIKFPNHRAQVPAIN 488

  Fly   470 DLGFFAYHSLDVIGVLLGGAL----LLVAIIVGVLGK-LTDFGNAKKKLKS 515
            .|||.|::.|||:..||..::    |.::::..|||| ||      ||.||
Worm   489 QLGFVAHYYLDVLLFLLVSSIVITYLAISLLKKVLGKCLT------KKTKS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	124/508 (24%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	115/462 (25%)
ugt-12	NP_504309.1	MGT	28..453	CDD:273616	114/456 (25%)
ugt-12	NP_504309.1	egt	<132..514	CDD:223071	107/404 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810