DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	148/547 - (27%)
Similarity:	235/547 - (42%)	Gaps:	98/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNA--FPQKKPVVNFRDVFI 71
            |.|.|..::.|.:.....|:...||........:.|||.||.||.::.  .|..|     .||.|
Worm     6 LFLLLLGAVSAYKYAVFVPYMANSQVQFCTRVAEVLANGGHDVTMIHLSHLPDYK-----TDVKI 65

  Fly    72 PDVFNNYK-----ELINELSGPMNLWQENNFI-------------------NKFFVSVTRCVLTN 112
            |   .|.|     ..:..|:..:...:::.||                   .|.|....|.::.|
Worm    66 P---KNIKVHRVEAYVEGLTKALLEKEQSAFIFKDTGLKDMPAMMSMFSRFGKMFQDGCRNIVRN 127

  Fly   113 KEVTETLLPPGKDHFDLI-----------IVEA--------LRSDAYYGFAAH-FNAPIIGISTF 157
            ||..:.|   ..:.||:.           ::.|        |.|.|...|.|. ...|||.
Worm   128 KEFMKWL---ENEKFDVAYSYIYSSCPIGLIHAAKIPSWVWLNSGALMDFVAETVGVPIIP---- 185

  Fly   158 GTDWNIDALVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYA--- 219
                            ||.|.......|.|.|..|:.:|:..|:..:.:|.:..:.:.:::.
Worm   186 ----------------SYVPPLMMESDDEMGFFFRMKSFIGHTLMTVLHRRMTSNGETQIFRDEL 234

  Fly   220 --KYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEF 281
              ..||..      .||.....||::|.:.....|||.:..::.:|||.:....| ||..:.::
Worm   235 NDPNFPHT------MDLGAKCPLVIVNSNELYDLPRPTLAKVVNIGGLGVGFDSAKPLTGEFKK- 292

  Fly   282 IQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQ-RVLWKFEDDKLPGK-PSNVFISKW 344
            |..:|: |:|.||.||...:.|:|.:.|:.||:.|:|||. :.|.::..|.|..: |.||.:.||
Worm   293 ISETGK-GMIVFSFGSVAAAHDMPLEWKNSILEAFSSLPDYQFLMRYVADDLNDRLPKNVHLFKW 356

  Fly   345 FPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMT 409
            .||.|:|.|.|.|.||||||..|..|:|..|.|::.:..|.||..|.:.|.:.||.:.:....::
Worm   357 LPQKDLLLHNKTKAFITHGGYNSMQEAISAGVPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEIS 421

  Fly   410 QQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFF 474
            ::.:.:.|..:::...:.|...::|...|.|||.|.:..:.|:|::...|...::..|||.|.||
Worm   422 KKTIVKAIMEIVENDSYKQKVSRLSAMVRAQPMKPAERLLKWSEFLAEFKTLDNLEPAGQKLNFF 486

  Fly   475 AYHSLDVIGVLLGGALLLVAIIVGVLG 501
            .|||||||..     |.:|..||..:|
Worm   487 QYHSLDVITF-----LFIVIFIVFYIG 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	130/510 (25%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	118/465 (25%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	141/516 (27%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	72/221 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I2570
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14329
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860