DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	176/561 - (31%)
Similarity:	270/561 - (48%)	Gaps:	90/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVN--- 65
            |..|||.|.|..|:...::|.: |..| |.::::...::.|:.|||.:..:      .|.||
  Rat    10 LPAGFLFLVLWGSVLGDKLLVV-PQDG-SHWLSMKEIVEHLSERGHDIVVL------VPEVNLLL 66

  Fly    66 -----FRDVFIPDVFN------NYKELINE-------LSGPMNLWQENNFINK--FFV------- 103
                 :|....|..:|      .|:...|.       |..|:..::.|..:..  ||.
  Rat    67 GESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFSCQSLLKD 131

  Fly   104 SVTRCVLTNKE----VTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNID 164
            |.|...|...:    .|:..:|.|     :|:.|.|:..:.|.|.             |...:::
  Rat   132 SATLSFLRENQFDALFTDPAMPCG-----VILAEYLKLPSVYLFR-------------GFPCSLE 178

  Fly   165 ALVG-NESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEAS-- 226
            .::| :.||:||.|......:|.|||.:||:||:...:.  ||.: |.     :|:||...||
  Rat   179 HMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILE--NYLY-HC-----LYSKYEILASDL 235

  Fly   227 -KR-VQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHG 289
             || |.|..|::| ||.||...|...:|||.:||||.:||.:.. |...|.::.|.::..|||||
  Rat   236 LKRDVSLPALHQN-SLWLLRYDFVFEYPRPVMPNMIFIGGTNCK-KKGNLSQEFEAYVNASGEHG 298

  Fly   290 VIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHP 354
            ::.|||||.|  .::|..:...|.:....:||.|||::...:......|..:.||.||.|:|.||
  Rat   299 IVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHP 361

  Fly   355 KVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEI 419
            |.:.||||.|.....|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:|:..::.
  Rat   362 KARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKT 426

  Fly   420 LLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGV 484
            ::....:.:...::|..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||||||||.
  Rat   427 VINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 491

  Fly   485 LLGGALLLVAIIVGVL---------GKLTDFGNAKKKLKSK 516
            ||...|.:|.|:....         ||    |..||..|||
  Rat   492 LLAIVLTVVFIVYKSCAYGCRKCFGGK----GRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	149/496 (30%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	127/450 (28%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	166/527 (31%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	164/536 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860