Protein Alignment Ugt35B1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_524313.2
• Gene: Ugt35B1 / 41333
• FlyBaseID: FBgn0026314
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 175/510 - (34%)
• Similarity: 264/510 - (51%)
• Gaps: 42/510 - (8%)

  Fly    32 SQYINVVPYLKELANRGHQVT----SVNAFPQKKP--VVNFRDVFIPDVFNNYKELINEL----- 85
            |.::|:...|:||..|.|.||    |...|....|  .|||..:.:....:|...||..:
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 305

  Fly    86 ---SGPMNLW----QENNFINKFF-VSVTRC--VLTNKEVTETLLPPGKDHFDLIIVE--ALRSD 138
               ..|:.:|    :....::.|| :::..|  ||.|.::...|...|   ||:::.:  .:..|
Human   306 DHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGG---FDVLVADPVTICGD 367

  Fly   139 AYYGFAAHFNAPIIGISTFGTDWNIDALVGN-ESPLSYTPLATGGLTDRMTFLERLSNFVDTTVA 202
            .   .|.....|.:....|.....::...|. .:|:||.|.|...|||:|||.||:.|.:..::.
Human   368 L---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQ 429

  Fly   203 WLNYRF-VHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLH 266
              :|.| .:..|....|:|..   .:...|.:......:.|:..::...|||||:||...|||||
Human   430 --DYIFQSYWGEWNSYYSKIL---GRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLH 489

  Fly   267 ISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDD 330
            .  ||| ||||::|||||.||::||:.|||||.|  |:|..::.:||....|.:||:|||:::..
Human   490 C--KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKANLIASALAQIPQKVLWRYKGK 550

  Fly   331 KLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRAT 395
            |.....:|..:..|.||.|:|.|||.|.||||||.....|:|:||.|::|:|.|.||..|:....
Human   551 KPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMK 615

  Fly   396 QAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKG 460
            ..|..:.::..|||..:|...:..::.||.:.:.|.::|..:.|||:.|||.|::|.|:|:||||
Human   616 AKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKG 680

  Fly   461 AYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVG-VLGKLTDFGNAKKKLK 514
            |.|:|||..||.:|.||||||||.||......:.:::. .|.....||...||.|
Human   681 AKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKK 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	Glycosyltransferase_GTB-type	<171..482	CDD:471961	129/312 (41%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	170/498 (34%)