DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	546	Identity:	177/546 - (32%)
Similarity:	278/546 - (50%)	Gaps:	63/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGP-SQYINVVPYLKELANRGHQVTSV--NAF----PQKKP---- 62
            |||.:....::.:...:..:|.. |.::|:...|.||..|||:||.:  :|:    |:|.|
Mouse    10 LLLQISCCFRSVKCGKVLVWPMEFSHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKF 74

  Fly    63 ---------------VVNFRDVF---IP-DVFNNYKELINELSGPMNLWQENNFINKF---FVSV 105
                           .:.|.||:   :| |...:|..|:            .|.|::|   |:|:
Mouse    75 ETFPTSVSKDNLENFFIKFVDVWTYEMPRDTCLSYSPLL------------QNMIDEFSDYFLSL 127

  Fly   106 TRCVLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGN- 169
            .:.|::|||:. |.|...|  ||:::.:.:.|.... .|.....|.:....|...:.|:...|.
Mouse   128 CKDVVSNKELM-TKLQESK--FDVLLSDPVASCGEL-IAELLQIPFLYSIRFSPGYQIEKSSGRF 188

  Fly   170 ESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPE-ASKRVQLTD 233
            ..|.||.|:...||..:|||:||:.|.    :..|.:.|......:|.:..::.| ..:...|.:
Mouse   189 LLPPSYVPVILSGLGGQMTFIERVKNM----ICRLYFDFWFQMFNDKKWDSFYSEYLGRPTTLAE 249

  Fly   234 LNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGS 297
            ......:.|:..::.|.||.|.:||:..|||||.  ||| |||||:|||:|.||:|||:.|||||
Mouse   250 TMGKAEMWLIRSNWDLEFPHPTLPNVDYVGGLHC--KPAKPLPKDMEEFVQSSGDHGVVVFSLGS 312

  Fly   298 NVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGK-PSNVFISKWFPQPDILAHPKVKLFIT 361
            .|  .::..::.:.|....|.:||:||||| |.|.|.. ..|..:.||.||.|:|.|||.|.|:|
Mouse   313 MV--SNMTEEKANTIAWALAQIPQKVLWKF-DGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVT 374

  Fly   362 HGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRF 426
            |||.....|.|:||.|::|:|.|.:|..|:......|..:.|:..||::.::...:|.::..|.:
Mouse   375 HGGANGVYEVIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPFY 439

  Fly   427 AQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLG-GAL 490
            .:.|..:|..:.|||..|||.|::|.|:|:|||.|.|:|..|.:|.:..||.|||||.||. .|:
Mouse   440 KKNAIWLSTIHHDQPTKPLDRAVFWVEFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVAV 504

  Fly   491 LLVAIIVGVLGKLTDFGNAKKKLKSK 516
            .:|..:..:|.....|...:||:|::
Mouse   505 TIVLTVKCLLFIYRFFVKKEKKIKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	158/493 (32%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	140/448 (31%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	171/520 (33%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	171/526 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840425
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690