DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	536	Identity:	162/536 - (30%)
Similarity:	267/536 - (49%)	Gaps:	82/536 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT--------SVNAFPQKKPVVN 65
            ||:|:|. :::..:| :||. ..|.::|:...::.|..:||.:|        .:..|......||
Zfish    17 LLVTVPV-VESGNVL-VFPV-DVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHYTSVN 78

  Fly    66 FR------DVFIPDVFNNYKELINE------LSGPMNLWQENNFINKFFVSVTRCVLTNKEVTET 118
            .:      :.||....:....::.|      |...:.:||    .:...:.:.|.::||....:.
Zfish    79 LKSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQ----TSLKMIEIEREMITNMIEDQQ 139

  Fly   119 LLPP-GKDHFDLIIVEALRSDAYYG--FAAHF-NAPIIGISTFGTDWNIDALVGN------ESPL 173
            |:.. .|..||||:.:    .|.||  ...|: ..||:    :...|.|   .|.      .|||
Zfish   140 LMQSLKKAKFDLILTD----PAMYGGVMLGHYLKLPIV----YNVRWTI---FGEGHFAIAPSPL 193

  Fly   174 SYTPLATGGLTDRMTFLERLSNFV-----DTTVAWL---NY-----RFVHMSEQEKMYAKYFPEA 225
            ||.|:....:.|||:||||:.|.|     :|.:|:|   .|     ||:.            ||
Zfish   194 SYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNALCERFIG------------PE- 245

  Fly   226 SKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHG 289
               |...:|.:...|.|....|...:|||.:||::.:.|...  ||: |||:|||:|:|.||:||
Zfish   246 ---VNFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQC--KPSKPLPQDLEDFVQSSGDHG 305

  Fly   290 VIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHP 354
            ||..|||:  |...||.|..:.|.:.||.|||:::|:::..:.....:|..:..|.||.|:|.||
Zfish   306 VIVMSLGT--LIGQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLLGHP 368

  Fly   355 KVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEI 419
            |.:.|:.|||.....|:|:||.|::|....:||..|:.:....|....:|..||.::...:|::.
Zfish   369 KTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKE 433

  Fly   420 LLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGV 484
            :|.:|.:.:..:::|..::|.|:.|||.||:|.|:|:|||||.|:|.....:.:::|||:|||.|
Zfish   434 VLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILV 498

  Fly   485 LLGGALLLVAIIVGVL 500
            |:....|::..|..|:
Zfish   499 LISAVSLIILSIYAVI 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	150/500 (30%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	129/455 (28%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	158/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584495
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790