DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	567	Identity:	171/567 - (30%)
Similarity:	278/567 - (49%)	Gaps:	92/567 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LALRIGFL-LLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT------------- 52
            :.|.:.|| |||:.::.|...||..  :...|.:||:...|..|.:|||.||
Zfish     1 MRLVVCFLSLLTVFSAGQCGNILVW--YTEGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAK 63

  Fly    53 -----SVNAFPQKKPVVNFRDVFIPDVFNNYKELINELSGPMNLWQENN--FIN---KFF----- 102
                 |...|...|...:.:|.|        .||:.     .::::.:|  |:.   |||
Zfish    64 ESDRFSYQHFSVSKSAQDMQDFF--------DELMR-----FSVFEMDNSSFLEIQMKFFNLGSQ 115

  Fly   103 ---VSVTRC--VLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYG----FAAHFNAPIIGISTFG 158
               :|::.|  :|.:.|:.:.|   .|..||:::     ||..|.    .|...|.|::....|.
Zfish   116 HQDMSLSYCDGILKSPELMDKL---KKGKFDVVL-----SDPMYPCSDIVAEELNVPLVYTFRFS 172

  Fly   159 TDWNIDALVGN-ESPLSYTPLATGGLTDRMTFLERLSNFV-----DTTVAWLNYRFVHMSEQEKM 217
            .....:.:.|. .:|.||.|.|...|||:|:|.||:.|.:     ||....:..||      :..
Zfish   173 VAHAAERMCGQIPAPPSYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRF------DNY 231

  Fly   218 YAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEF 281
            |.:||   .:.....::.....:.|:..::...||||:|||...:||||.:  || |||||:|||
Zfish   232 YTEYF---GRSTSYCEMMGKADIWLIRTYWDFEFPRPFVPNFKYIGGLHCT--PAKPLPKDMEEF 291

  Fly   282 IQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFP 346
            :|.||:.|::.|:|||.:  ..:|.:..:.|....|.:||:|||::..:|......|..|.||.|
Zfish   292 VQSSGDDGIVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWIP 354

  Fly   347 QPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDH-TTMTQ 410
            |.|:|.|||.:.||||||.....|:|:||.|::|:|.|.||..|:...|.....:.:|. .:|..
Zfish   355 QNDLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQP 419

  Fly   411 QELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFA 475
            |||.:.:..::.:|.:.:.|.::|..:.|:||.|||.:::|.|:|:|:|||.|:||...:|.::.
Zfish   420 QELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQ 484

  Fly   476 YHSLDVIGVLLGGALLLVAIIVGVLGKLTDF------GNAKKKLKSK 516
            ||.|||...|    ..::.:::.:..|:..|      ..:|:|.|.:
Zfish   485 YHCLDVFAFL----TTVLTLVLYICFKMAKFFIMRCCFRSKRKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	156/503 (31%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	134/456 (29%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	162/542 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860