DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4757 and CES2

DIOPT Version :10

Sequence 1:NP_650043.1 Gene:CG4757 / 41330 FlyBaseID:FBgn0027584 Length:550 Species:Drosophila melanogaster
Sequence 2:NP_003860.3 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:601 Identity:173/601 - (28%)
Similarity:262/601 - (43%) Gaps:138/601 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLVLL-------ASSSVLSIEVDTELG---RVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVN 63
            ||:||       ::|.:.:......||   .|:|||    .||  ..|.||.:|:||||.|||..
Human    17 LLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGAN----AGV--QTFLGIPFAKPPLGPLRFAP 75

  Fly    64 PQPVKPWSPKIFDASEDGPMCPQPWD----------NMT----DVSEDCLRLNVYT--KDLKGRR 112
            |:|.:.|| .:.|.:....||.|...          |||    .:|||||.|::||  ...:|..
Human    76 PEPPESWS-GVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSN 139

  Fly   113 -PVIVFLHPGGFYVFSGQSKY----LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGL 172
             ||:|::| ||..||...|.|    ||..|     :.|:|.:.||||.|||.:||.|.|.||.|.
Human   140 LPVMVWIH-GGALVFGMASLYDGSMLAALE-----NVVVVIIQYRLGVLGFFSTGDKHATGNWGY 198

  Fly   173 KDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKY 237
            .|||.||||:||:|..|||:||.||:.|.|||..||:..::||:|:||||..|..|.....|...
Human   199 LDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLI 263

  Fly   238 KDNDLQLAKRQAGLLKCPQESIGEMVECMR----------RKPYLDYVSTYNGMFEFGWNPVLNW 292
            ..:...::...|.|..|.|.....:|.|:|          .||:.......:|:|          
Human   264 ASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVF---------- 318

  Fly   293 RIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHY 357
                         |...|.:.....||..|..|.|:...||                   .| ..
Human   319 -------------LPRHPQELLASADFQPVPSIVGVNNNEF-------------------GW-LI 350

  Fly   358 ASIALLLEQNSTQSRAASR------------------VFREKYMPESLDKLEYPKSLKG-MGELL 403
            ..:..:.:......|.||:                  :.||:|:.::.|    |::|:. ..|::
Human   351 PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGD----PQTLQAQFQEMM 411

  Fly   404 SDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKN--PDNQQTIGPVHHDELIYLFHVGLLI 466
            :|::..:...:.........|:|.|.|:::.  ::|||  |.:.:.   .|.|||.::|......
Human   412 ADSMFVIPALQVAHFQCSRAPVYFYEFQHQP--SWLKNIRPPHMKA---DHGDELPFVFRSFFGG 471

  Fly   467 PLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIGNNLTAKSG 530
            ..:|..:.|..:...:.:.|..||:.|:|:.      :|| :|||:: |::.||::  ||....|
Human   472 NYIKFTEEEEQLSRKMMKYWANFARNGNPNG------EGLPHWPLFD-QEEQYLQL--NLQPAVG 527

  Fly   531 -GFFLNRYQIWEDLFP 545
             ....:|.|.|:...|
Human   528 RALKAHRLQFWKKALP 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4757NP_650043.1 COesterase 20..540 CDD:395084 166/576 (29%)
CES2NP_003860.3 COesterase 30..538 CDD:395084 167/581 (29%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.

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