Protein Alignment CG4757 and CES2

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 173/601 - (28%)
• Similarity: 262/601 - (43%)
• Gaps: 138/601 - (22%)

  Fly     9 LLVLL-------ASSSVLSIEVDTELG---RVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVN 63
            ||:||       ::|.:.:......||   .|:|||    .||  ..|.||.:|:||||.|||..
Human    17 LLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGAN----AGV--QTFLGIPFAKPPLGPLRFAP 75

  Fly    64 PQPVKPWSPKIFDASEDGPMCPQPWD----------NMT----DVSEDCLRLNVYT--KDLKGRR 112
            |:|.:.|| .:.|.:....||.|...          |||    .:|||||.|::||  ...:|..
Human    76 PEPPESWS-GVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSN 139

  Fly   113 -PVIVFLHPGGFYVFSGQSKY----LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGL 172
             ||:|::| ||..||...|.|    ||..|     :.|:|.:.||||.|||.:||.|.|.||.|.
Human   140 LPVMVWIH-GGALVFGMASLYDGSMLAALE-----NVVVVIIQYRLGVLGFFSTGDKHATGNWGY 198

  Fly   173 KDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKY 237
            .|||.||||:||:|..|||:||.||:.|.|||..||:..::||:|:||||..|..|.....|...
Human   199 LDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLI 263

  Fly   238 KDNDLQLAKRQAGLLKCPQESIGEMVECMR----------RKPYLDYVSTYNGMFEFGWNPVLNW 292
            ..:...::...|.|..|.|.....:|.|:|          .||:.......:|:|
Human   264 ASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVF---------- 318

  Fly   293 RIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHY 357
                         |...|.:.....||..|..|.|:...||                   .| ..
Human   319 -------------LPRHPQELLASADFQPVPSIVGVNNNEF-------------------GW-LI 350

  Fly   358 ASIALLLEQNSTQSRAASR------------------VFREKYMPESLDKLEYPKSLKG-MGELL 403
            ..:..:.:......|.||:                  :.||:|:.::.|    |::|:. ..|::
Human   351 PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGD----PQTLQAQFQEMM 411

  Fly   404 SDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKN--PDNQQTIGPVHHDELIYLFHVGLLI 466
            :|::..:...:.........|:|.|.|:::.  ::|||  |.:.:.   .|.|||.::|......
Human   412 ADSMFVIPALQVAHFQCSRAPVYFYEFQHQP--SWLKNIRPPHMKA---DHGDELPFVFRSFFGG 471

  Fly   467 PLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIGNNLTAKSG 530
            ..:|..:.|..:...:.:.|..||:.|:|:.      :|| :|||:: |::.||::  ||....|
Human   472 NYIKFTEEEEQLSRKMMKYWANFARNGNPNG------EGLPHWPLFD-QEEQYLQL--NLQPAVG 527

  Fly   531 -GFFLNRYQIWEDLFP 545
             ....:|.|.|:...|
Human   528 RALKAHRLQFWKKALP 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	167/581 (29%)
		Aes	40..>204	CDD:223730	81/184 (44%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	167/581 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840