Protein Alignment CG4757 and Ache

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_038945765.1
• Gene: Ache / 83817
• RGDID: 69313
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 601
• Identity: 198/601 - (32%)
• Similarity: 292/601 - (48%)
• Gaps: 117/601 - (19%)

  Fly     3 MLFVVELLVLLASSSVLSIEVDTE-LGRVRGANLTS-RL---GVNFHAFRGIRYAEPPLGDLRFV 62
            :||:  ||.||...:......|.: |.||||..|.. ||   |....||.||.:||||:|..||:
  Rat    17 LLFL--LLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFM 79

  Fly    63 NPQPVKPWSPKIFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLK--GRR 112
            .|:|.:||| .|.||:....:|.|             .|:...::|||||.|||:|...:  ...
  Rat    80 PPEPKRPWS-GILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPT 143

  Fly   113 PVIVFLHPGGFYVFSGQS-------KYLAGPEHFMDRDCVLVSLNYRLGSLGFLA-TGSKEAPGN 169
            ||:::::.||||  ||.|       ::||..|     ..||||:|||:|:.|||| .||::||||
  Rat   144 PVLIWIYGGGFY--SGASSLDVYDGRFLAQVE-----GTVLVSMNYRVGTFGFLALPGSRDAPGN 201

  Fly   170 AGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGP 234
            .||.||.|||:|:|::|..|||||.||||.|.|||:.||.:|:||..||.||||.:..|..|.||
  Rat   202 VGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGP 266

  Fly   235 VKYKDNDLQLAKRQAGLLK----CPQESIG----EMVECMRRKPYLD------YVSTYNGMFEFG 285
              :.......|:|:|.||.    ||....|    |::.|:|.:|..|      :|.....:|.|.
  Rat   267 --WATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFS 329

  Fly   286 WNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAF--------FDLR 342
            :.|      ||:.||     |.::|......|||..:.::.|:.:.|   |::        |...
  Rat   330 FVP------VVDGDF-----LSDTPEALINTGDFQDLQVLVGVVKDE---GSYFLVYGVPGFSKD 380

  Fly   343 NESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDAL 407
            |||:::|.    :..|.:.:.:.|       ||.:..|..:....|.| :|:....:.:.:| |:
  Rat   381 NESLISRA----QFLAGVRIGVPQ-------ASDLAAEAVVLHYTDWL-HPEDPAHLRDAMS-AV 432

  Fly   408 IGVSFHRFL--------QLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGL 464
            :|  .|..:        :|.:....:|.|:|.:  |.:.|..|   ..:|..|..|:.::|  ||
  Rat   433 VG--DHNVVCPVAQLAGRLAAQGARVYAYIFEH--RASTLTWP---LWMGVPHGYEIEFIF--GL 488

  Fly   465 -LIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY-------LEI 521
             |.|.|.....|....:.|.:.|..||:.|||::..|.  |...||.|....:.|       ||:
  Rat   489 PLDPSLNYTVEERIFAQRLMKYWTNFARTGDPNDPRDS--KSPRWPPYTTAAQQYVSLNLKPLEV 551

  Fly   522 GNNLTAKSGGFFLNRY 537
            ...|.|::..|: ||:
  Rat   552 RRGLRAQTCAFW-NRF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	192/584 (33%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	188/573 (33%)