Protein Alignment CG4757 and Ces1h

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001357759.1
• Gene: Ces1h / 75704
• MGIID: 1922954
• Length: 562
• Species: Mus musculus
• Alignment Length: 589
• Identity: 171/589 - (29%)
• Similarity: 264/589 - (44%)
• Gaps: 133/589 - (22%)

  Fly    23 VDTELGRVRG-----ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGP 82
            |:|..|:|.|     ...|..:.|    |.|:.:|:||||.|||..|||.:||| .:.:|:...|
Mouse    26 VNTTHGKVLGKYISLEGFTQPVAV----FLGVPFAKPPLGSLRFAPPQPPEPWS-FVKNATSYPP 85

  Fly    83 MCPQP-----------WDNMTDV----SEDCLRLNVYTK-DL---KGRRPVIVFLHPGGFYVFSG 128
            ||.|.           .:|...:    |||||.|||||. ||   ..|.||:|::|.||. |..|
Mouse    86 MCSQDAVLGQMVNDLIINNKEKIRLRFSEDCLYLNVYTPVDLMKNTNRLPVMVWIHGGGL-VVGG 149

  Fly   129 QSKY----LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRF 189
            .|.|    |:..|     :.|:|::.|||...||.:||.:.:.||.|..||:.||.|||.:|..|
Mouse   150 ASAYDGRTLSAHE-----NVVVVTIQYRLAIWGFFSTGDEHSRGNWGHLDQLAALHWIQDNIANF 209

  Fly   190 GGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKC 254
            ||||.|||:.|.|||..||::.:|||:::.||||.|..|...:....:.::...:.::.|....|
Mouse   210 GGDPGSVTIFGQSAGGESVSVLVLSPLAKNLFHRAISQSGVVFTSGLFMEDASSVTEQIAVTAGC 274

  Fly   255 PQESIGEMVECMRRK---PYLDYVSTYNGMFE----------FGWNPVLNWRIVVEKDFGQERYL 306
            ...:...:|.|:|:|   ..|:.:...| :|:          :.:.|.:...:|:.|  ..|..|
Mouse   275 KTTTSAVIVHCLRQKTEEELLEIMQKMN-LFKLDAQENTKKNYPFLPTVLDGVVLPK--APEAIL 336

  Fly   307 IESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQS 371
            .|..|.|        |..|.||.:.||                   .|    ::.:::|...|..
Mouse   337 AEKNFNT--------VPYIVGINKQEF-------------------GW----TLPMIMEFPPTDV 370

  Fly   372 RAASRV---FREKY-----MPESLDKLEYPKSLKG----------MGELLSDALIGVSF------ 412
            :...:|   |..|.     :||....:...|..||          :.:|:.|.:.|:..
Mouse   371 KLDKKVISLFLRKLAYFFNIPEDGIPVAIEKYSKGTDDPIQNRVWLLQLIGDVMFGIPSVIVSRG 435

  Fly   413 HRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKR--EDPE 475
            ||     ....|.|.|.|:.:..::....|   :|:...|.||:..:|..    |:|:.  .:.|
Mouse   436 HR-----DAGAPTYMYEFQSRPSFSSELKP---KTVTGDHGDEVYSVFGA----PILREGSSEEE 488

  Fly   476 NFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQI 539
            ..:.:::.:.|..||:.|:|:.      :|| :||.|| |.||||:||.. |.::.|.......:
Mouse   489 INLSKMMMKFWANFARNGNPNG------QGLPHWPEYN-QKKGYLQIGAT-TQQAQGLKDKEVSL 545

  Fly   540 WEDL 543
            |.:|
Mouse   546 WTEL 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	169/584 (29%)
		Aes	40..>204	CDD:223730	78/186 (42%)
Ces1h	NP_001357759.1	COesterase	24..546	CDD:365897	169/584 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890