DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	165/564 - (29%)
Similarity:	261/564 - (46%)	Gaps:	97/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DTELGRVRGA---NLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCP 85
            :|.:|:|||.   ...::.||  |.|.||.:|:||:|.|||..|:..:||| .:.|.:....||.
  Rat    37 NTHIGQVRGKLDHVKDTKAGV--HTFLGIPFAKPPVGPLRFAPPEAPEPWS-GVRDGTSQPAMCL 98

  Fly    86 QPWDNM--------------TDVSEDCLRLNVYT-------KDLKGRRPVIVFLHPGGFYVFSGQ 129
            |..|.:              ..:|||||.||:|.       .:|    ||:|::|.||  :.:|.
  Rat    99 QNLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAHEGSNL----PVMVWIHGGG--LMTGM 157

  Fly   130 SKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPD 194
            :....|....::.|.|:|::.||||.|||.:||.:.|.||.|..|||.||||:||:|..|||:||
  Rat   158 ASMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPD 222

  Fly   195 SVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESI 259
            .||:.|.|||...|:.|::||||:||||..|..|.....|....|.....:...|.:..|.....
  Rat   223 RVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPYLIADTSEMFSTMVAKVSGCEAMDS 287

  Fly   260 GEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNW-RIVVEKDFGQERYLIESPFKTARRGDFHKVA 323
            ..:|.|:|.|...:.::.         |.|:.. ..||:.:|     |...|.:.....||..|.
  Rat   288 EALVHCLRAKSEAEILAI---------NKVVQMVPAVVDGEF-----LPRHPKELLASEDFRPVP 338

  Fly   324 LITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQ---SRAASRVFREKYMPE 385
            .|.|:...|:.......:....::...:|:     ::..:|::.:.|   ....|.:..|:||.:
  Rat   339 SIIGVNNDEYGWTIPLVMGTTQMIKELSRE-----NLQAILKKTTAQLMLPLECSDLLMEEYMGD 398

  Fly   386 SLDKLEYPKSLKG-MGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIG 449
                :|.||:|:. ..||:.|.:..:...:.......|.|:|.|.|::  :.||||:      |.
  Rat   399 ----IEDPKTLQAQFTELMEDFMFVIPALQVAHFQCSHAPVYFYEFQH--QITFLKD------IR 451

  Fly   450 PVH----H-DELIYLFHVGLLIPLLKRE--DPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLN 507
            |.|    | ||:.::|  |.....:|.:  :.|..:...:.:.|..||:.|:|:::...|
  Rat   452 PPHVKADHGDEIPFVF--GYFFWDMKTDFTEEEKLLSRRMMKYWANFARHGNPNSEGLSY----- 509

  Fly   508 WPLYNAQDKGYLE------IGNNLTAKSGGFFLNRYQIWEDLFP 545
            ||:.: .|:.||:      :|..|.|:       |.|.|....|
  Rat   510 WPVMD-HDQQYLQLDTQPAVGRALKAR-------RLQFWTKTLP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	163/557 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	74/184 (40%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	163/557 (29%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	46/108 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336314
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.890