Protein Alignment CG4757 and BCHE

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 178/589 - (30%)
• Similarity: 284/589 - (48%)
• Gaps: 93/589 - (15%)

  Fly     4 LFVVELLVLLASSSVL--SIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQP 66
            ||...||.:|...|..  .|.:.|:.|:|||.|||. .|....||.||.||:||||.|||..||.
Human    13 LFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTV-FGGTVTAFLGIPYAQPPLGRLRFKKPQS 76

  Fly    67 VKPWSPKIFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLKGRR-PVIVF 117
            :..|| .|::|::....|.|             .|:..||:|||||.|||:....|.:. .|:::
Human    77 LTKWS-DIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIW 140

  Fly   118 LHPGGF-------YVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLA-TGSKEAPGNAGLKD 174
            ::.|||       :|:.|  |:||..|.     .::||:|||:|:||||| .|:.|||||.||.|
Human   141 IYGGGFQTGTSSLHVYDG--KFLARVER-----VIVVSMNYRVGALGFLALPGNPEAPGNMGLFD 198

  Fly   175 QVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSA---APYGPV- 235
            |.|||:|:|::|..|||:|.||||.|.|||:.||:||:|||.|..||.|.|..|.   ||:...
Human   199 QQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTS 263

  Fly   236 --KYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEK 298
              :.::..|.|||    |..|.:|:..|:::|:|.|...:.:.....:..:|....:|:...|:.
Human   264 LYEARNRTLNLAK----LTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDG 324

  Fly   299 DFGQERYLIESPFKTARRGDFHKVALITGI-----TEFEFLSGAFFDLRNESIVNRYNRDWEHYA 358
            ||     |.:.|......|.|.|..::.|:     |.|.......|...|.||:.|  ::::...
Human   325 DF-----LTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITR--KEFQEGL 382

  Fly   359 SIALLLEQNSTQSRAASRVFREKYMPESLDKL--EYPKSLK-GMGELLSDALIGVSFHRFLQLMS 420
            .|..         ...|...:|..:....|.:  :.|::.: .:|:::.|       :.|:....
Human   383 KIFF---------PGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGD-------YNFICPAL 431

  Fly   421 PHTPIYT------YLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRED---PEN 476
            ..|..::      :.:.::.|.:.|..|   :.:|.:|..|:.::|  ||  ||.:|::   .|.
Human   432 EFTKKFSEWGNNAFFYYFEHRSSKLPWP---EWMGVMHGYEIEFVF--GL--PLERRDNYTKAEE 489

  Fly   477 FMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWE 541
            .:...:.:.|..||:.|:|   |:......:||::.:.::.||.:....|.........:.:.|.
Human   490 ILSRSIVKRWANFAKYGNP---NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWT 551

  Fly   542 DLFP 545
            ..||
Human   552 SFFP 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	169/564 (30%)
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	169/565 (30%)
		AChE_tetra	565..599	CDD:430146