DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4757 and NLGN2

DIOPT Version :10

Sequence 1:NP_650043.1 Gene:CG4757 / 41330 FlyBaseID:FBgn0027584 Length:550 Species:Drosophila melanogaster
Sequence 2:NP_065846.1 Gene:NLGN2 / 57555 HGNCID:14290 Length:835 Species:Homo sapiens


Alignment Length:644 Identity:174/644 - (27%)
Similarity:264/644 - (40%) Gaps:191/644 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VDTELGRVRGA--NLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCP 85
            |:|..|||||.  .|.:.:......|.|:.||.||||..||..|:....| |.:.:|:...|.||
Human    44 VNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASW-PGVRNATTLPPACP 107

  Fly    86 Q------------PW--DNM-------TDVSEDCLRLNVY--------TK------------DLK 109
            |            .|  ||:       .:.|||||.||:|        ||            |::
Human   108 QNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIR 172

  Fly   110 --GRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD-------RDCVLVSLNYRLGSLGFLATGSKE 165
              |::||::|||.|         .|:.|..:..|       .:.::.:||||||.||||:||.:.
Human   173 DPGKKPVMLFLHGG---------SYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQA 228

  Fly   166 APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMS-- 228
            |.||.||.||:.||||:.::|..|||||:.:|:.|..||:..|.|.:||..|.|||.:.|..|  
Human   229 AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGT 293

  Fly   229 -----AAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYV--STYNGMFEFGW 286
                 :..|.|:||       .:..|..:.|.:|...|.|||:||||..:.|  ......:...:
Human   294 AISSWSVNYQPLKY-------TRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAF 351

  Fly   287 NPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFL-------------SGAF 338
            .||::..:|.           :.|....::|:|....::.|:.:.|.|             |.:.
Human   352 GPVVDGDVVP-----------DDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASA 405

  Fly   339 FDLRNESIV-NRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGM--- 399
            ||....:.| |.|.                               .||..|.|.  :::|.|   
Human   406 FDFTVSNFVDNLYG-------------------------------YPEGKDVLR--ETIKFMYTD 437

  Fly   400 ------GELLSDALIGV-SFHRFLQLMSP-----------HTPIYTYLFRYKGRYTFLKNPDNQQ 446
                  ||:....|:.: :.|   |.::|           .:|:|.|.|     |...:.....:
Human   438 WADRDNGEMRRKTLLALFTDH---QWVAPAVATAKLHADYQSPVYFYTF-----YHHCQAEGRPE 494

  Fly   447 TIGPVHHDELIYLFHVGLLIPLLKRED--PENF------MIELLTRMWIEFAQKGDP-------- 495
            .....|.|||.|:|.|    |::...|  |.||      :..::...|..||:.|||        
Human   495 WADAAHGDELPYVFGV----PMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDT 555

  Fly   496 ---HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP-LSSFH 550
               |.|.:.: :.:.|..:|:::|.||.||.....:. .:..|:...|.:|.| |.:.|
Human   556 KFIHTKPNRF-EEVVWSKFNSKEKQYLHIGLKPRVRD-NYRANKVAFWLELVPHLHNLH 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4757NP_650043.1 COesterase 20..540 CDD:395084 169/631 (27%)
NLGN2NP_065846.1 COesterase 42..601 CDD:395084 169/631 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..668
Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9 678..698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..835
Blue background indicates that the domain is not in the aligned region.

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