Protein Alignment CG4757 and NCEH1

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001139748.2
• Gene: NCEH1 / 57552
• HGNCID: 29260
• Length: 416
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 96/513 - (18%)
• Similarity: 172/513 - (33%)
• Gaps: 195/513 - (38%)

  Fly    31 RGA----NLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQPWDN- 90
            |||    ||...||::.|           |..|.|:    :..:..|            ..|.:
Human    41 RGAQQVSNLIHYLGLSHH-----------LLALNFI----IVSFGKK------------SAWSSA 78

  Fly    91 ---MTDVSEDCLRLNVYTKDLKGRRPV---IVFLHPGGFYVFSGQSKYLAGPE-HFMDRDC---- 144
               :||...|.:.:.|:....|...|:   :|::|.||:.:.|..:.:....| .:.|..|
Human    79 QVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASASASWSPSDEIRYYDELCTAMA 143

  Fly   145 -----VLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWI--QQHIQRFGGDPDSVTLLGYS 202
                 |:||:.|||....:..         ..:.|.|.|.::.  .:.:|::..||..:.:.|.|
Human   144 EELNAVIVSIEYRLVPKVYFP---------EQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDS 199

  Fly   203 A-GSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECM 266
            | |:::.||.........|                  .|.|:|           |..|..:::.:
Human   200 AGGNLAAALGQQFTQDASL------------------KNKLKL-----------QALIYPVLQAL 235

  Fly   267 --RRKPYLDYVSTYNGMFEFGWNPVLNWRIVVE--KDFGQERYLIESPFKTARRGDFHKVALITG 327
              ....|...|:|          |:|...::|:  .|:.:..|            ||.:..::..
Human   236 DFNTPSYQQNVNT----------PILPRYVMVKYWVDYFKGNY------------DFVQAMIVNN 278

  Fly   328 ITEFEFLSGAFFDLRNESIVNRYNRDW---------EHYASIALLLEQNSTQSRAASRVFREKYM 383
            .|..:.         .|:...|...:|         ::|..:        .|:...:|:.:|  :
Human   279 HTSLDV---------EEAAAVRARLNWTSLLPASFTKNYKPV--------VQTTGNARIVQE--L 324

  Fly   384 PESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTI 448
            |:.||....|        |::|..:       |||: |.|.|.|.      .:..|::
Human   325 PQLLDARSAP--------LIADQAV-------LQLL-PKTYILTC------EHDVLRD------- 360

  Fly   449 GPVHHDELIY---LFHVGLLIPLLKRED-----------PENFMIELLTR----MWIE 488
                 |.::|   |...|:.:.|...||           |.||.:.:.||    .|::
Human   361 -----DGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLD 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	96/513 (19%)
NCEH1	NP_001139748.2	Abhydrolase_3	109..389	CDD:400284	71/392 (18%)