Protein Alignment CG4757 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 169/641 - (26%)
• Similarity: 271/641 - (42%)
• Gaps: 147/641 - (22%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGAN--LTSRLGVNFHAFRGIRYAEPPLGDLRFVN 63
            :|.|..:.:...|..|......|:|..|::||..  |.:.:......:.|:.||.||.|:.||..
Human    26 LLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQP 90

  Fly    64 PQPVKPWSPKIFDASEDGPMCPQPWDN-------------------MT---DVSEDCLRLNVY-- 104
            |:|...|: .|.:.::...:|||..|.                   ||   |.:||||.||:|
Human    91 PEPPSSWT-GIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVP 154

  Fly   105 ------TK------------------DLKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD---- 141
                  ||                  |...::||:|::|.|         .|:.|..:.:|
Human   155 TEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGG---------SYMEGTGNMIDGSIL 210

  Fly   142 ---RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSA 203
               .:.:::::|||||.||||:||.:.|.||.||.||:.|||||::::..|||||..||:.|..|
Human   211 ASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGA 275

  Fly   204 GSISVALHMLSPMSRGLFHRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGE 261
            |:..|:|..||..|.|||.:.|..|       |..|.|.||       .:..|..:.|......:
Human   276 GASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKY-------TRILADKVGCNMLDTTD 333

  Fly   262 MVECMRRKPYLDYV------STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFH 320
            ||||:|.|.|.:.:      :||:  ..||  ||::..::.:    ..:.|:|       :|:|.
Human   334 MVECLRNKNYKELIQQTITPATYH--IAFG--PVIDGDVIPD----DPQILME-------QGEFL 383

  Fly   321 KVALITGITEFEFLSGAFFD--LRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFRE--K 381
            ...::.|:.:.|.|.  |.|  :.||..|...:.|:    |::..:: |...........||  |
Human   384 NYDIMLGVNQGEGLK--FVDGIVDNEDGVTPNDFDF----SVSNFVD-NLYGYPEGKDTLRETIK 441

  Fly   382 YMPESLDKLEYPKS-LKGMGELLSD------ALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFL 439
            :|.......|.|:: .|.:..|.:|      |:.....|  .|..||     ||.:.:   |...
Human   442 FMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLH--AQYGSP-----TYFYAF---YHHC 496

  Fly   440 KNPDNQQTIGPVHHDELIYLFHVGLLIP--LLKREDPEN--FMIELLTRMWIEFAQKGDP----- 495
            ::..........|.||:.|:|.:.::.|  |......:|  .:..::...|..||:.|||
Human   497 QSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVP 561

  Fly   496 ------HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
                  |.|.:.: :.:.|..||.:|:.||.||.....:. .:...:...|.:|.|
Human   562 QDTKFIHTKPNRF-EEVAWSKYNPKDQLYLHIGLKPRVRD-HYRATKVAFWLELVP 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	162/615 (26%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	162/616 (26%)