Protein Alignment CG4757 and Aadac

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_065413.1
• Gene: Aadac / 57300
• RGDID: 631440
• Length: 398
• Species: Rattus norvegicus
• Alignment Length: 481
• Identity: 97/481 - (20%)
• Similarity: 164/481 - (34%)
• Gaps: 143/481 - (29%)

  Fly     4 LFVVELLVLLASSSVLSIEVDTE------LGRV---RGANLTS---RLGVNFHAFRGIRYAEPPL 56
            :|::..:||:|....:.:..|.|      ||..   .|.:|.|   .||:| |....::.
  Rat     5 IFLLISVVLVAYYIYIPLPDDIEEPWKIILGNTLLKLGGDLASFGELLGLN-HFMDTVQL----- 63

  Fly    57 GDLRFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMTDVSEDCLRLNVYTKDLKGRRPVIVFLHPG 121
                |:..|.|.|.|.:.....|            ||.:...:|:.:..:.....|..:.|:|.|
  Rat    64 ----FMRFQVVPPTSDENVTVME------------TDFNSVPVRIYIPKRKSTTLRRGLFFIHGG 112

  Fly   122 G-------FYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPG---NAGLKDQV 176
            |       ::::...|:..|   |.:  |.|:||.:|.|            ||.   ....:|..
  Rat   113 GWCLGSAAYFMYDTLSRRTA---HRL--DAVVVSTDYGL------------APKYHFPKQFEDVY 160

  Fly   177 LALRWIQQH--IQRFGGDPDSVTLLGYSAG---SISVALHMLSPMSRGLFHRGICMSAAPYGPVK 236
            .:|||..|.  ::::|.||..|.:.|.|||   :.:|...:|..               |...:|
  Rat   161 HSLRWFLQEDILEKYGVDPRRVGVSGDSAGGNLTAAVTQQILQD---------------PDVKIK 210

  Fly   237 YKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTY---------------------NG 280
            .|...|.....||..:..|.:........:.|...:.:.|.|                     :.
  Rat   211 LKVQALIYPALQALDMNVPSQQENSQYPLLTRSLLIRFWSEYFTTDRDLEKAMLLNQHVPVEFSH 275

  Fly   281 MFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNES 345
            :.:|     :||..::     .:||.....:||...|.........|.|:.:    |...|.|:|
  Rat   276 LLQF-----VNWSSLL-----PQRYKKGYFYKTPTPGSLELAQKYPGFTDVK----ACPLLANDS 326

  Fly   346 IVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGV 410
            |:        |:..:..::       .....|.|:       |.|.|.|.|:..|..::...|..
  Rat   327 IL--------HHLPMTYII-------TCQYDVLRD-------DGLMYVKRLQNTGVHVTHHHIED 369

  Fly   411 SFHRFLQLMSPHTPIYTYLFRYKGRY 436
            .||..|.|     |.....:|.:.:|
  Rat   370 GFHGALTL-----PGLKITYRMQNQY 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	93/465 (20%)
Aadac	NP_065413.1	Abhydrolase_3	106..373	CDD:400284	66/334 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)