DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and ces3

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001038401.1	Gene:	ces3 / 560651	ZFINID:	ZDB-GENE-030131-9563	Length:	549	Species:	Danio rerio

Alignment Length:	566	Identity:	168/566 - (29%)
Similarity:	243/566 - (42%)	Gaps:	136/566 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GRVRGANLTSR-LGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMC------- 84
            |.|||..:.:: .......:.||.:|:||:|..|...||||:.|. .|.:|:|...||
Zfish    34 GSVRGQYVKAKGSPAVVEQYLGIPFAQPPVGPHRLAAPQPVQGWE-GIRNATEYSSMCLQDPNIV 97

  Fly    85 PQPWDNM------TDVSEDCLRLNVYTKDLKG---RRPVIVFLHPGGFYVFSGQSKYLAGPEHFM 140
            |:...:|      |.||||||.|||||...:.   :.||:|::| ||..|..|...|...|....
Zfish    98 PKYAKSMTLELPPTGVSEDCLYLNVYTPSQRSESDKFPVMVWIH-GGALVIGGACMYDGTPLAAY 161

  Fly   141 DRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGS 205
            :: .|:|.:.||||.||:|:||.:.|.||.|..||:.||:|:||:|:.|||||.|||:.|.|||.
Zfish   162 EK-VVVVVIQYRLGILGYLSTGDQHAQGNWGFLDQIAALQWVQQNIEAFGGDPQSVTIAGESAGG 225

  Fly   206 ISVALHMLSPMSRGLFHRGICMS-AAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMR-- 267
            ||.:|..||||::|||.|.|..| .|......:|| .|..||..|.:.:|...|...:|:|:|
Zfish   226 ISASLLTLSPMTKGLFQRAIFQSGVATVKGYSFKD-PLTYAKVIANITECDFSSSEVLVKCIREM 289

  Fly   268 ---------RKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVA 323
                     :|.|....:|.:|.|                       :...|.:..:..||.|:.
Zfish   290 TEEQIIKAAQKKYRLPGATVDGEF-----------------------IKAQPEEILKSKDFPKIP 331

  Fly   324 LITGITEFEF---LSGAFFDLRNESIVNRYNRDW-----EHYASIALLLEQNSTQSRA----ASR 376
            ::.|.|..||   ||.|...           :||     ...|...|....|:..|.|    |..
Zfish   332 ILVGTTNHEFGWTLSHAILP-----------KDWAKGMDAKSAKQTLDFFYNAGASEANGIIADE 385

  Fly   377 VFREKYMPESLDKLEYPKSLKGMGELLSDALIGV------SFHRFLQLMSPHTPIYTYLFRY--- 432
            .|:....||.:        .....|||.|.::.:      |:||     ....|:|.|.|::
Zfish   386 YFKNAKTPEEI--------RDAFTELLGDIIMVIPSIKVASYHR-----DAGAPVYMYEFQHGPS 437

  Fly   433 ---KGRYTFLKNPDNQQTIGPVHHDELIYLFH----------VGLLIPLLKREDPENFMIELLTR 484
               |.|.:|:|..         |.||:.::|.          .|.|      .:.||.:...:.:
Zfish   438 IANKFRPSFVKAD---------HGDEIGFMFGACFWDGQVKVTGTL------TEEENQLCRTVMK 487

  Fly   485 MWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSG 530
            .|..|.:.|.|:.      ..:.||:|:..:| ||.:|...|...|
Zfish   488 YWANFVRTGSPNP------APVPWPVYDQSNK-YLNLGLQQTEGQG 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	168/566 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	74/179 (41%)
ces3	NP_001038401.1	COesterase	24..535	CDD:278561	168/566 (30%)
ces3	NP_001038401.1	Aes	<122..>235	CDD:223730	52/114 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575331
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3697
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.990