Protein Alignment CG4757 and nlgn2a

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_009301340.1
• Gene: nlgn2a / 556158
• ZFINID: ZDB-GENE-090918-2
• Length: 828
• Species: Danio rerio
• Alignment Length: 689
• Identity: 179/689 - (25%)
• Similarity: 277/689 - (40%)
• Gaps: 232/689 - (33%)

  Fly     2 LMLFVVELLVLLASSSVLS-----IEVDTELGRVRG--ANLTSRLGVNFHAFRGIRYAEPPLGDL 59
            :.||.:.|.:.|||...:.     ..|.|..|::||  ..|.:.:......:.|:.||..|:||.
Zfish    23 IALFWLALWITLASCQRIDPGTKYPTVTTNYGKLRGIKKELNNEILGPVEQYLGVPYATAPIGDR 87

  Fly    60 RFVNPQPVKPWSPKIFDASEDGPMCPQ------------PW--DNMTDV--------SEDCLRLN 102
            ||..|:....|. ::.:|::..|:|||            .|  |:: ||        |||||.||
Zfish    88 RFQPPEAPGSWQ-EVRNATQFAPVCPQNVHGVLPEIMLPVWFTDSL-DVAATYIQNQSEDCLYLN 150

  Fly   103 VYT---------------------KDLKGRR--PVIVFLHPGGFYVFSGQSKYLAGPEHFMDR-- 142
            ||.                     :|::.||  ||::|:|.|         .|:.|..:..|.
Zfish   151 VYVPTEDGPLTKKHDESTLNRPRDEDIRDRRKKPVMLFIHGG---------SYMEGTGNMFDASV 206

  Fly   143 -----DCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYS 202
                 :.::|::|||||.||||:||.:.|.||.||.||:.||||:.::|..|||||:.:|:.|..
Zfish   207 LAAYGNVIVVTMNYRLGVLGFLSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSG 271

  Fly   203 AGSISVALHMLSPMSRGLFHRGICMSAA-------PYGPVKYKDNDLQLAKRQAGLLKCPQESIG 260
            ||:..|.|.:||..|.|||.|.|..|.:       .|.|:||    .::..|:.|   |......
Zfish   272 AGASCVNLLILSHHSEGLFQRAIAQSGSAISSWSISYQPLKY----TKILARKVG---CTYGETA 329

  Fly   261 EMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLI------------ESPFKT 313
            ::|:|:|||                     |:|.:|::|....||.|            :.|...
Zfish   330 DLVDCLRRK---------------------NFRELVDQDIQPARYHIAFGPVMDGDVVPDDPEIL 373

  Fly   314 ARRGDFHKVALITGITEFEFL--------------SGAFFDLRNESIV-NRYNRDWEHYASIALL 363
            .::|:|....|:.|:.:.|.|              |.|.||....:.| |.|.
Zfish   374 MQQGEFLNYDLLIGVNQGEGLKFVDDGGTESEEGISAAAFDYTISNFVDNLYG------------ 426

  Fly   364 LEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGM---------GELLSDALIGV-SFHRFLQL 418
                               .|:..|.|.  :::|.|         ||:....|:.: :.|   |.
Zfish   427 -------------------YPKGKDILR--ETIKFMYTDWADRDNGEMRRKTLLALFTDH---QW 467

  Fly   419 MSP-----------HTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRE 472
            ::|           .:|:|.|.|     |...:.....:.....|.||:.|:|.|    |::...
Zfish   468 VAPAIATAKLHADYQSPVYFYTF-----YHHCQTETRPEWADAAHGDEIPYVFGV----PMIGAT 523

  Fly   473 D--PENF------MIELLTRMWIEFAQKGDP-----------HNKNDEYLKGLNWPLYNAQDKGY 518
            |  |.||      :..::...|..||:.|||           |.|.:.: :.:.|..:|::||.|
Zfish   524 DLFPCNFSKNDIMLSAVVMTYWTNFAKTGDPNLPVPQDTKFIHTKPNRF-EEVIWTKFNSKDKQY 587

  Fly   519 LEIG------NNLTAKSGGFFLNRYQIWEDLFP-LSSFH 550
            |.||      :|..|       |:...|.:|.| |.:.|
Zfish   588 LHIGLKPRIRDNYRA-------NKVAFWLELVPHLHNLH 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	168/658 (26%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:395084	168/652 (26%)