Protein Alignment CG4757 and NLGN3

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 175/679 - (25%)
• Similarity: 269/679 - (39%)
• Gaps: 212/679 - (31%)

  Fly    10 LVLLASSSVLSIEVDTELGRVRGAN--LTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSP 72
            |.|.||:...:..|:|..|::|||.  |.|.:......:.|:.||.||:|:.||:.|:|...||
Human    31 LALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWS- 94

  Fly    73 KIFDASEDGPMCPQ------------PW---------DNMTDVSEDCLRLNVY--TKDLK----- 109
            .|.:|:...|:|||            .|         ..:.:.:||||.||||  |:|:|
Human    95 GIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKE 159

  Fly   110 --------------------------------------GRRPVIVFLHPGGFYVFSGQSKYLAGP 136
                                                  |.:||:|::|.|         .|:.|.
Human   160 CARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGG---------SYMEGT 215

  Fly   137 EHFMD-------RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPD 194
            .:.:|       .:.::::||||:|.||||:||.:.|.||.||.||:.||||:.::|..|||||.
Human   216 GNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPR 280

  Fly   195 SVTLLGYSAGSISVALHMLSPMSRGLFHRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLL 252
            .:|:.|...|:..|:|..||..|.|||.|.|..|       |..|.||||    ..|...:.|
Human   281 RITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKY----TSLLADKVG-- 339

  Fly   253 KCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLI---------- 307
             |......:||:|:|:|                     :.:.:||:|....||.:
Human   340 -CNVLDTVDMVDCLRQK---------------------SAKELVEQDIQPARYHVAFGPVIDGDV 382

  Fly   308 --ESPFKTARRGDFHKVALITGITEFEFL-------------SGAFFDLRNESIV-NRYNRDWEH 356
              :.|.....:|:|....::.|:.:.|.|             ||..||....:.| |.|...
Human   383 IPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYP--- 444

  Fly   357 YASIALLLEQNSTQSRAASRVFRE--KYMPESLDKLEYPKS-LKGMGELLSD------ALIGVSF 412
                    |...|        .||  |:|.......:.|:: .|.:..|.:|      :::....
Human   445 --------EGKDT--------LRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADL 493

  Fly   413 H-RFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRED--P 474
            | |:      .:|.|.|.| |....:.:|...:.    ..|.||:.|:|.|    |::...|  |
Human   494 HARY------GSPTYFYAF-YHHCQSLMKPAWSD----AAHGDEVPYVFGV----PMVGPTDLFP 543

  Fly   475 ENF------MIELLTRMWIEFAQKGDP-----------HNKNDEYLKGLNWPLYNAQDKGYLEIG 522
            .||      :..::...|..||:.|||           |.|.:.: :.:.|..||.:|:.||.||
Human   544 CNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRF-EEVAWSKYNPRDQLYLHIG 607

  Fly   523 NNLTAKSGGFFLNRYQIWEDLFP-LSSFH 550
            .....:. .:...:...|:.|.| |.:.|
Human   608 LKPRVRD-HYRATKVAFWKHLVPHLYNLH 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	166/656 (25%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	166/657 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694