Protein Alignment CG4757 and ACHE

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 200/610 - (32%)
• Similarity: 292/610 - (47%)
• Gaps: 133/610 - (21%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTEL------GRVRGANLTSRLGVNFHAFRGIRYAEPPLGDL 59
            :|:|    ||.||..........|.||      ||:||..|.:. |....||.||.:||||:|..
Human    84 LLLL----LLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTP-GGPVSAFLGIPFAEPPMGPR 143

  Fly    60 RFVNPQPVKPWSPKIFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLK-- 109
            ||:.|:|.:||| .:.||:....:|.|             .|:...::|||||.|||:|...:
Human   144 RFLPPEPKQPWS-GVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT 207

  Fly   110 GRRPVIVFLHPGGFY-------VFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLA-TGSKEA 166
            ...||:|:::.||||       |:.|  ::|...|.     .||||:|||:|:.|||| .||:||
Human   208 SPTPVLVWIYGGGFYSGASSLDVYDG--RFLVQAER-----TVLVSMNYRVGAFGFLALPGSREA 265

  Fly   167 PGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAP 231
            |||.||.||.|||:|:|:::..|||||.||||.|.|||:.||.:|:|||.|||||||.:..|.||
Human   266 PGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAP 330

  Fly   232 YGPVKYKDNDLQLAKRQ----AGLLKCPQESIG----EMVECMRRKP------YLDYVSTYNGMF 282
            .||  :....:..|:|:    |.|:.||....|    |:|.|:|.:|      :..:|.....:|
Human   331 NGP--WATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVF 393

  Fly   283 EFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAF--------F 339
            .|.:.|      ||:.||     |.::|......||||.:.::.|:.:.|   |::        |
Human   394 RFSFVP------VVDGDF-----LSDTPEALINAGDFHGLQVLVGVVKDE---GSYFLVYGAPGF 444

  Fly   340 DLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLS 404
            ...|||:::|.    |..|.:.:.:.|.|..:..|..:....::        :|:....:.|.||
Human   445 SKDNESLISRA----EFLAGVRVGVPQVSDLAAEAVVLHYTDWL--------HPEDPARLREALS 497

  Fly   405 DALIGVSFHRFL--------QLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFH 461
            |.   |..|..:        :|.:....:|.|:|.:  |.:.|..|   ..:|..|..|:.::|.
Human   498 DV---VGDHNVVCPVAQLAGRLAAQGARVYAYVFEH--RASTLSWP---LWMGVPHGYEIEFIFG 554

  Fly   462 VGLLIPLLKREDP-------ENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY- 518
                |||    ||       |....:.|.|.|..||:.|||:...|.  |...||.|.|..:.|
Human   555 ----IPL----DPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDP--KAPQWPPYTAGAQQYV 609

  Fly   519 ------LEIGNNLTAKSGGFFLNRY 537
                  ||:...|.|::..|: ||:
Human   610 SLDLRPLEVRRGLRAQACAFW-NRF 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	194/591 (33%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	190/580 (33%)
		AChE_tetra	645..678	CDD:430146