DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and alpha-Est7

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	632	Identity:	184/632 - (29%)
Similarity:	261/632 - (41%)	Gaps:	206/632 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMC 84
            ::..|||.|:|||....|...|.:.:|.||.||:||:|:|||..||...||. ::.|       |
  Fly    32 TVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWE-RVRD-------C 88

  Fly    85 PQPWDNMTDV---------SEDCLRLNVYTKDLK--GRRPVIVFLHPGGFYVFSGQSKYLAGPEH 138
            .||.|....|         |||||.|||||.::|  ..|||:|::|.|||.:.....::. ||::
  Fly    89 SQPKDKAVQVQFVFDKVEGSEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWY-GPDY 152

  Fly   139 FMDRDCVLVSLNYRLGSLGFLATGSKE--APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGY 201
            ||..|.|||::.||||:|||::..|.|  .|||||||||||||:||:.:...|||||:.:|:.|.
  Fly   153 FMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGE 217

  Fly   202 SAGSISVALHMLSPMSRGLFHRGICMSAA--------------PYGPVK---YK--DND------ 241
            |||..|....||:..::|||||||..|.:              ||...|   ||  |||
  Fly   218 SAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEF 282

  Fly   242 LQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYL 306
            ||..|.: .|::. :|::..:.|.|.:.           ||.||  |.|       :.|.....:
  Fly   283 LQNVKAK-DLIRV-EENVLTLEERMNKI-----------MFAFG--PSL-------EPFSTPECV 325

  Fly   307 IESP----FKTARRGDFHKVALITGITEFEFL-----------------SGAFFDLRNESIVNRY 350
            |..|    .|||..   :.:.:..|.|.:|.|                 :|..| :..|.:....
  Fly   326 ISKPPKEMMKTAWS---NSIPMFIGNTSYEGLLWVPEVKLMPQVLQQLDAGTPF-IPKELLATEP 386

  Fly   351 NRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRF 415
            :::         .|:..|.|.|...|...|......:|                  |..:.:..|
  Fly   387 SKE---------KLDSWSAQIRDVHRTGSESTPDNYMD------------------LCSIYYFVF 424

  Fly   416 LQLMSPHT--------PIYTYLFRYKGRYTFLKNPDNQQTIGPV-------------HHDELIYL 459
            ..|...|:        |:|.|      ||.|    |:::.|.|.             |.|:|.|.
  Fly   425 PALRVVHSRHAYAAGAPVYFY------RYDF----DSEELIFPYRIMRLGRGVKGVSHADDLSYQ 479

  Fly   460 FHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHN---------------KNDEYLKGLN-- 507
            |. .||...|.:|..|...||....:|.:||..|:|::               |:||.:|.||
  Fly   480 FS-SLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTIDPVRKSDEVIKCLNIS 543

  Fly   508 ----------WPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLF 544
                      ||                          :.::||.|:
  Fly   544 DDLKFIDLPEWP--------------------------KLKVWESLY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	181/626 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	81/176 (46%)
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	172/554 (31%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	53/105 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467404
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800