DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	169/559 - (30%)
Similarity:	247/559 - (44%)	Gaps:	124/559 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQPW 88
            ||..|:|:|....|..|.|:::|.||.:|:||:|:|||..|...:.||    |......:..:|.
  Fly    36 DTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWS----DVKRCTHVRAKPC 96

  Fly    89 D-----NMTDVSEDCLRLNVYTKDLKGRR--PVIVFLHPGGFYVFSGQ-SKYLAGPEHFMDRDCV 145
            .     .....|||||.|||||::|...|  ||:|:::.|||.:  |: |:.|..|::.|....|
  Fly    97 QVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQM--GEASRDLYSPDYIMMEHVV 159

  Fly   146 LVSLNYRLGSLGFLATGSKE--APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISV 208
            ||.::||||:||||:...:|  .||||||||||:||||::::.|.||||||::|:.|.|||..|.
  Fly   160 LVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGAST 224

  Fly   209 ALHMLSPMSRGLFHRGICMSAA--------------PY---------GPVKYKDNDLQLAKRQAG 250
            ...||:..::||||:.|.||.:              ||         |....:|....|.|.:|.
  Fly   225 HYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKAS 289

  Fly   251 LLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFG--WNPVLNWRIVVEKDFGQERYLIESPFKT 313
            .:....|.|..|.|..:|..          ||.||  ..|.|....|:.|          ||.:.
  Fly   290 SMLKVAEDIITMEERHQRLT----------MFSFGPTIEPYLTPHCVIPK----------SPLEM 334

  Fly   314 ARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNR------DWEHYASIALLLEQNSTQSR 372
            .|....:.:.::.|...||.|  ..|     ..||::..      |.|:.|.....:::.  |.:
  Fly   335 MRDCWGNSIPMVIGGNSFEGL--LMF-----PEVNKWPELLCQLGDCENLAPQDAHVDEQ--QRK 390

  Fly   373 AASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIY-TYLFRYK--- 433
            |..:..||.|..   |:....|::....:|.|........||.|...:.|.|:. |:|:|:.
  Fly   391 AFGKKVRELYFG---DRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDS 452

  Fly   434 -----------GRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELLTRMWI 487
                       ||          :..|..|.|:|.|||: ......|||...|...|:.|..|.:
  Fly   453 KHFNIMRIITCGR----------KVRGTCHADDLSYLFY-NAAAKKLKRRTAEFKTIKRLVSMVV 506

  Fly   488 EFAQKGDPH-------------------NKNDEYLKGLN 507
            .||..|||:                   :|:|:..:.||
  Fly   507 HFAISGDPNIPMVCQDEKEQPRGAWLPISKDDKVFQCLN 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	169/559 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	76/173 (44%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	169/559 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	53/106 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467389
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790